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  <headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <previousAccessionNumber>0001085146-25-001725</previousAccessionNumber>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001907884</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>1</amendmentNo>
      <securitiesClassTitle>Common Shares, no par value per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>12/31/2025</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001980845</issuerCik>
        <issuerName>enGene Holdings Inc.</issuerName>
        <issuerCusip>29286M105</issuerCusip>
        <issuerPrincipalExecutiveOfficeAddress>
          <ns1:street1>4868 RUE LEVY, SUITE 220</ns1:street1>
          <ns1:city>SAINT-LAURENT</ns1:city>
          <ns1:stateOrCountry>A8</ns1:stateOrCountry>
          <ns1:zipCode>H4R 2P1</ns1:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Kynam Capital Management, LP</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>1492898</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>1492898</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1492898</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.23</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Kynam Capital Management GP, LLC</reportingPersonName>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>1492898</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>1492898</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1492898</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.23</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>
      <reportingPersonName>Yue Tang</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>1492898</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>1492898</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1492898</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.23</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>enGene Holdings Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>4868 RUE LEVY, SUITE 220, SAINT-LAURENT, QUEBEC, CANADA
H4R 2P1</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Kynam Capital Management, LP

Kynam Capital Management GP, LLC

Yue Tang</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>221 ELM ROAD
PRINCETON, New Jersey
08540</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Kynam Capital Management, LP - DELAWARE

Kynam Capital Management GP, LLC - DELAWARE

Yue Tang - UNITED STATES</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>1,492,898
</amountBeneficiallyOwned>
        <classPercent>2.23</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>Kynam Capital Management, LP - 0

Kynam Capital Management GP, LLC - 0

Yue Tang - 0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>Kynam Capital Management, LP - 1,492,898

Kynam Capital Management GP, LLC - 1,492,898

Yue Tang - 1,492,898</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>Kynam Capital Management, LP - 0

Kynam Capital Management GP, LLC - 0

Yue Tang - 0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>Kynam Capital Management, LP - 1,492,898

Kynam Capital Management GP, LLC - 1,492,898

Yue Tang - 1,492,898</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Kynam Capital Management, LP</reportingPersonName>
      <signatureDetails>
        <signature>Yue Tang</signature>
        <title>Managing Member</title>
        <date>02/17/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Kynam Capital Management GP, LLC</reportingPersonName>
      <signatureDetails>
        <signature>Yue Tang</signature>
        <title>Managing Member</title>
        <date>02/17/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Yue Tang</reportingPersonName>
      <signatureDetails>
        <signature>Yue Tang</signature>
        <title>Self</title>
        <date>02/17/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
