X0202 SCHEDULE 13G 0001787258 XXXXXXXX LIVE Common Stock, par value $0.0001 per share 03/31/2026 0001979414 NEONC TECHNOLOGIES HOLDINGS, INC. 64051A101 23975 Park Sorrento Suite 205 Calabasas CA 91302 Rule 13d-1(b) Cinctive Capital Management LP DE 0 2483980 0 2483980 2483980 N 9.99 IA PN See disclosure in Item 4 Cinctive GP LLC DE 0 2483980 0 2483980 2483980 N 9.99 OO HC See disclosure in Item 4 Richard H. Schimel X1 0 2483980 0 2483980 2483980 N 9.99 IN HC See disclosure in Item 4 Lawrence J. Sapanski X1 0 2483980 0 2483980 2483980 N 9.99 IN HC See disclosure in Item 4 NEONC TECHNOLOGIES HOLDINGS, INC. 23975 Park Sorrento, Suite 205, Calabasas, California, 91302 This Statement is filed on behalf of each of (i) Cinctive Capital Management LP, (ii) Cinctive GP LLC, the general partner of Cinctive Capital Management LP, and (iii) Richard H. Schimel and Lawrence J. Sapanski, the co-founders and co-Chief Investment Officers of Cinctive Capital Management LP and managing members of Cinctive GP LLC (collectively, the "Reporting Persons"). The address of each Reporting Person is 50 Hudson Yards, 67th Floor, New York, NY 10001. Cinctive Capital Management LP is a Delaware limited partnership. Cinctive GP LLC is a Delaware limited liability company. Richard H. Schimel and Lawrence J. Sapanski are citizens of the United States. N IA HC As of March 31, 2026, each of the Reporting Persons may be deemed the beneficial owner of 2,483,980 shares of Common Stock, which amount consists of 1,425,526 shares of Common Stock and 1,058,454 shares of Common Stock that the Reporting Persons have the right to acquire upon exercise of Warrants, subject to the Blocker (as defined herein). The Issuer shall not effect any exercise of the Warrants, and the Reporting Persons shall not have the right to exercise any portion of the Warrants, to the extent that after giving effect to such issuance after exercise, the Reporting Persons (together with the Reporting Persons' affiliates, and any other persons or entities acting as a group together with the Reporting Persons or any of the Reporting Persons' affiliates), would beneficially own in excess of 9.99% of the number of shares of Common Stock outstanding immediately after giving effect to the issuance of shares of Common Stock issuable upon exercise of Warrants, subject to a potential increase provided that any increase will not be effective until the 61st day after the Reporting Persons deliver notice of such increase to the Issuer (the "Blocker"). As of March 31, 2026, each of the Reporting Persons may be deemed the beneficial owner of approximately 9.99% of the shares of Common Stock outstanding. This percentage is based on (i) 23,806,216 shares of Common Stock outstanding as of March 30, 2026, as reported in the Issuer's annual report on Form 10-K filed with the Securities and Exchange Commission on March 31, 2026, and (ii) 1,058,454 shares of Common Stock issuable to the Reporting Persons within 60 days upon exercise of Warrants, subject to the Blocker, which shares of Common Stock have been added to the total shares of Common Stock outstanding in accordance with Rule 13d-3(d)(1)(i) under the Securities Exchange Act of 1934, as amended. 0 2,483,980 0 2,483,980 Y N See disclosure in Items 2 and 4 hereof. Cinctive Global Master Fund, Ltd has the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, more than 5 percent of the shares of Common Stock covered by this statement that may be deemed to be beneficially owned by the Reporting Persons. N See disclosure in Item 2 hereof. Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 1: Joint Filing Agreement Cinctive Capital Management LP /s/ Richard H. Schimel 05/15/2026 Cinctive GP LLC /s/ Richard H. Schimel 05/15/2026 Richard H. Schimel /s/ Richard H. Schimel 05/15/2026 Lawrence J. Sapanski /s/ Lawrence J. Sapanski 05/15/2026