144 0001983476 XXXXXXXX LIVE 0001974640 APOGEE THERAPEUTICS INC 001-41740 221 Crescent St., Building 17 Suite 102b Waltham MA 02453 6503945230 CARL DAMBKOWSKI Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

16500 2190045.00 61902733 07/01/2026 NASDAQ Common 07/01/2026 Exercise of Stock Options Issuer N 12375 07/01/2026 Cash Common 12/14/2022 Restricted Stock Awards Issuer N 4125 12/14/2022 N/A N 10b5-1 Sales for CARL DAMBKOWSKI

221 Crescent St., Building 17 Suite 102b Waltham MA 02453

Common 06/22/2026 26400 3500574.00 10b5-1 Sales for CARL DAMBKOWSKI

221 Crescent St., Building 17 Suite 102b Waltham MA 02453

Common 06/03/2026 5500 432905.00 10b5-1 Sales for CARL DAMBKOWSKI

221 Crescent St., Building 17 Suite 102b Waltham MA 02453

Common 05/06/2026 5500 462768.35 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 07/01/2026 09/22/2025 /s/ Carl Dambkowski