X0508 4 2024-10-02 0 0001974640 Apogee Therapeutics, Inc. APGE 0001779990 HENDERSON MICHAEL THOMAS C/O APOGEE THERAPEUTICS, INC. 221 CRESCENT ST., BLDG. 17, STE. 102B WALTHAM MA 02453 1 1 0 0 Chief Executive Officer 1 Common Stock 2024-10-02 4 S 0 30288 56.07 D 1364199 D Common Stock 2024-10-02 4 S 0 9712 56.74 D 1354487 D This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on September 25, 2023. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $55.51 to $56.50, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission (the "SEC"), upon request, full information regarding the number of shares sold at each separate price within the range. The price reported above is a weighted average price. The shares were sold in multiple transactions at prices ranging from $56.52 to $57.11, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ Matthew Batters, as attorney-in-fact for Michael Henderson 2024-10-04