<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001970134</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000354950</issuerCik>
      <issuerName>HOME DEPOT, INC.</issuerName>
      <secFileNumber>001-08207</secFileNumber>
      <issuerAddress>
        <com:street1>2455 PACES FERRY ROAD</com:street1>
        <com:city>ATLANTA</com:city>
        <com:stateOrCountry>GA</com:stateOrCountry>
        <com:zipCode>30339-4024</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>770-433-8211</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Bastek William D</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>3455 Peachtree Road NE, Suite 1000</com:street1>
          <com:city>Atlanta</com:city>
          <com:stateOrCountry>GA</com:stateOrCountry>
          <com:zipCode>30326</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>2969</noOfUnitsSold>
      <aggregateMarketValue>1236909.75</aggregateMarketValue>
      <noOfUnitsOutstanding>993362612</noOfUnitsOutstanding>
      <approxSaleDate>11/22/2024</approxSaleDate>
      <securitiesExchangeName>NYSE</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>11/22/2024</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of a Stock Award</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Home Depot, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>2969</amountOfSecuritiesAcquired>
      <paymentDate>11/22/2024</paymentDate>
      <natureOfPayment>Compensatory Payment</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>11/22/2024</noticeDate>
      <signature>William D Bastek</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
