The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC COMM 00289Y206   3,943,819 624,022 SH   DFND 1 215,438 408,584 0
ACHIEVE LIFE SCIENCES INC COMM 004468500   11,627,656 2,453,092 SH   DFND 1 2,235,247 217,845 0
AKERO THERAPEUTICS INC COMM 00973Y108   9,861,585 343,729 SH   DFND 1 115,275 228,454 0
APPLIED THERAPEUTICS INC COMM 03828A101   55,826,793 6,567,858 SH   DFND 1 3,750,353 2,817,505 0
ARDELYX INC COMM 039697107   7,378,825 1,070,947 SH   DFND 1 381,583 689,364 0
AVIDITY BIOSCIENCES INC COMM 05370A108   8,198,505 178,500 SH   DFND 1 53,500 125,000 0
CHINOOK THERAPEUTICS COMM 169CVR016   9,750 79,357 SH   DFND 1 54,357 25,000 0
COMPASS PATHWAYS LTD COMM 20451W101   504,000 80,000 SH   SOLE   80,000 0 0
EIGER BIOPHARMACEUTICALS COMM 28249U204   1,244,239 146,381 SH   DFND 1 56,381 90,000 0
KURA ONCOLOGY INC COMM 50127T109   2,540,200 130,000 SH   DFND 1 50,000 80,000 0
KYMERA THERAPEUTICS INC COMM 501575104   2,667,471 56,359 SH   DFND 1 25,844 30,515 0
MADRIGAL PHARMACEUTICALS COMM 558868105   9,132,251 43,032 SH   DFND 1 19,738 23,294 0
PHATHOM PHARMACEUTICALS I COMM 71722W107   15,728,280 869,927 SH   DFND 1 347,992 521,935 0
SYNDAX PHARMACEUTICALS IN COMM 87164F105   2,565,236 133,259 SH   DFND 1 53,259 80,000 0
TSCAN THERAPEUTICS INC COMM 89854M101   10,393,952 2,087,139 SH   DFND 1 1,040,223 1,046,916 0
VERRICA PHARMACEUTICALS I COMM 92511W108   500,159 344,937 SH   DFND 1 144,937 200,000 0
ZEVRA THERAPEUTICS INC COMM 488445206   1,248,326 179,874 SH   DFND 1 59,874 120,000 0
MAAT PHARMA SACA COMM F5888J116   17,786 2,397 SH   DFND 1 0 2,397 0
TELESAT CORP COMM 879512309   4,817,336 365,781 SH   DFND 1 0 365,781 0
ATHIRA PHARMA INC COMM 04746L104   665,785 1,492,792 SH   DFND 1 0 1,492,792 0
PLAINS GP HOLDINGS LP-CL COMM 72651A207   23,538,660 1,272,360 SH   DFND 1 0 1,272,360 0