The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AGIOS PHARMACEUTICALS INC | COMM | 00847X104 | 128,988 | 5,792 | SH | DFND | 1 | 0 | 5,792 | 0 | ||
| AKERO THERAPEUTICS INC | COMM | 00973Y108 | 2,336,214 | 100,052 | SH | DFND | 1 | 40,275 | 59,777 | 0 | ||
| APPLIED THERAPEUTICS INC | COMM | 03828A101 | 18,006,190 | 5,374,982 | SH | DFND | 1 | 2,957,477 | 2,417,505 | 0 | ||
| ARDELYX INC | COMM | 039697107 | 3,683,879 | 594,174 | SH | DFND | 1 | 244,174 | 350,000 | 0 | ||
| ATHIRA PHARMA INC | COMM | 04746L104 | 3,627,485 | 1,492,792 | SH | DFND | 1 | 0 | 1,492,792 | 0 | ||
| AVIDITY BIOSCIENCES INC | COMM | 05370A108 | 1,615,425 | 178,500 | SH | DFND | 1 | 53,500 | 125,000 | 0 | ||
| CHINOOK THERAPEUTICS INC CVR | COMM | 169CVR016 | 0 | 79,357 | SH | DFND | 1 | 54,357 | 25,000 | 0 | ||
| CRINETICS PHARMACEUTICALS IN | COMM | 22663K107 | 5,870,700 | 165,000 | SH | DFND | 1 | 50,000 | 115,000 | 0 | ||
| CYBIN INC | COMM | 23256X100 | 348,500 | 850,000 | SH | DFND | 1 | 350,000 | 500,000 | 0 | ||
| DAY ONE BIOPHARMACEUTICALS I | COMM | 23954D109 | 3,951,694 | 270,664 | SH | DFND | 1 | 95,646 | 175,018 | 0 | ||
| EIGER BIOPHARMACEUTICALS INC | COMM | 28249U105 | 985,876 | 4,391,432 | SH | DFND | 1 | 1,691,432 | 2,700,000 | 0 | ||
| FIDELITY INV MMTRSY 1 680 | COMM | X9USDFIDT | 4,772,389 | 4,772,389 | SH | DFND | 1 | 0 | 4,772,389 | 0 | ||
| FULCRUM THERAPEUTICS INC | COMM | 359616109 | 5,062,500 | 750,000 | SH | DFND | 1 | 285,000 | 465,000 | 0 | ||
| HERON THERAPEUTICS INC | COMM | 427746102 | 177,132 | 104,195 | SH | SOLE | 104,195 | 0 | 0 | |||
| ISHARES 0-5 YR INV GRD CO | COMM | 46434V100 | 597,682 | 12,148 | SH | DFND | 1 | 0 | 12,148 | 0 | ||
| ISHARES IBONDS DEC 2024 T | COMM | 46434VBG4 | 2,128,360 | 85,442 | SH | DFND | 1 | 0 | 85,442 | 0 | ||
| ISHARES IBOXX INVESTMENT | COMM | 464287242 | 493,101 | 4,456 | SH | DFND | 1 | 0 | 4,456 | 0 | ||
| ISHARES MBS ETF | COMM | 464288588 | 2,107,392 | 22,400 | SH | DFND | 1 | 0 | 22,400 | 0 | ||
| KAYNE ANDERSON ENERGY INF | COMM | 486606106 | 1,290,950 | 147,033 | SH | DFND | 1 | 0 | 147,033 | 0 | ||
| KURA ONCOLOGY INC | COMM | 50127T109 | 1,869,400 | 130,000 | SH | DFND | 1 | 50,000 | 80,000 | 0 | ||
| KYMERA THERAPEUTICS INC | COMM | 501575104 | 1,434,900 | 56,359 | SH | DFND | 1 | 25,844 | 30,515 | 0 | ||
| MADRIGAL PHARMACEUTICALS INC | COMM | 558868105 | 6,948,804 | 30,032 | SH | DFND | 1 | 15,738 | 14,294 | 0 | ||
| MARINUS PHARMACEUTICALS INC | COMM | 56854Q200 | 1,957,687 | 180,100 | SH | DFND | 1 | 30,100 | 150,000 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COMM | 604749101 | 2,066,400 | 70,000 | SH | DFND | 1 | 0 | 70,000 | 0 | ||
| PHATHOM PHARMACEUTICALS INC | COMM | 71722W107 | 4,045,019 | 443,047 | SH | DFND | 1 | 205,112 | 237,935 | 0 | ||
| PLAINS GP HOLDINGS LP-CL | COMM | 72651A207 | 21,889,142 | 1,372,360 | SH | DFND | 1 | 0 | 1,372,360 | 0 | ||
| SIMPLIFY ENHANCED INCOME | COMM | 82889N632 | 2,952,628 | 120,221 | SH | DFND | 1 | 0 | 120,221 | 0 | ||
| SPDR BLOOMBERG INVESTMENT | COMM | 78468R200 | 283,478 | 9,267 | SH | DFND | 1 | 0 | 9,267 | 0 | ||
| SPDR PORT SHRT TRM CORP B | COMM | 78464A474 | 1,360,797 | 45,695 | SH | DFND | 1 | 0 | 45,695 | 0 | ||
| SUTRO BIOPHARMA INC | COMM | 869367102 | 836,550 | 195,000 | SH | DFND | 1 | 75,000 | 120,000 | 0 | ||
| TELESAT CORP | COMM | 879512309 | 3,032,846 | 290,781 | SH | DFND | 1 | 0 | 290,781 | 0 | ||
| TSCAN THERAPEUTICS INC | COMM | 89854M101 | 12,168,020 | 2,087,139 | SH | DFND | 1 | 1,040,223 | 1,046,916 | 0 | ||
| VANGUARD SHORT-TERM BOND | COMM | 921937827 | 2,134,378 | 27,712 | SH | DFND | 1 | 0 | 27,712 | 0 | ||
| X4 PHARMACEUTICALS INC | COMM | 98420X103 | 448,598 | 535,000 | SH | DFND | 1 | 135,000 | 400,000 | 0 | ||