The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
INVENTIVA SA ADS 46124U107   3,994,612 724,678 SH   DFND   496,755 227,923 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100   3,581,151 380,420 SH   DFND   309,990 70,430 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206   6,007,982 1,329,899 SH   DFND   829,557 500,342 0
ACHIEVE LIFE SCIENCES INC COM 004468500   11,368,992 3,786,425 SH   DFND   2,601,913 1,184,512 0
ALDEYRA THERAPEUTICS INC COM 01438T106   1,234,724 730,606 SH   DFND   730,606 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104   2,950,600 710,988 SH   DFND   710,988 0 0
ARTIVA BIOTHERAPEUTICS INC COM 04317A107   949,818 146,369 SH   DFND   123,139 23,230 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   4,135,129 131,364 SH   DFND   62,370 68,994 0
COHERUS ONCOLOGY INC COM 19249H103   2,413,387 1,420,550 SH   DFND   1,167,410 253,140 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101   4,117,846 742,049 SH   DFND   582,997 159,052 0
CONNECT BIOPHARMA HLDGS LTD SHS G23549101   553,909 209,493 SH   DFND   159,118 50,375 0
CORCEPT THERAPEUTICS INC COM 218352102   6,022,011 147,828 SH   DFND   110,065 37,763 0
CORVUS PHARMACEUTICALS INC COM 221015100   1,251,074 85,791 SH   DFND   65,549 20,242 0
DELCATH SYS INC COM NEW 24661P807   9,159,490 979,698 SH   DFND   718,572 261,126 0
EVOMMUNE INC COM SHS 30054Y107   1,279,715 55,664 SH   DFND   55,664 0 0
EYEPOINT INC COM NEW 30233G209   2,788,943 215,825 SH   DFND   162,299 53,526 0
IMMUNIC INC COM 4525EP101   2,620,262 2,344,779 SH   DFND   1,905,847 438,932 0
KALARIS THERAPEUTICS INC COM 482929106   1,721,024 295,771 SH   DFND   208,345 87,426 0
KYVERNA THERAPEUTICS INC COM 501976104   5,585,588 644,421 SH   DFND   471,315 173,106 0
MAZE THERAPEUTICS INC COM 578784100   1,307,370 43,798 SH   DFND   43,798 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   5,081,571 4,118,321 SH   DFND   2,611,916 1,506,405 0
NUVATION BIO INC COM CL A 67080N101   1,412,680 329,296 SH   DFND   329,296 0 0
OCULAR THERAPEUTIX INC COM 67576A100   3,226,116 382,375 SH   DFND   292,375 90,000 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102   3,279,243 122,223 SH   DFND   55,556 66,667 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   3,830,724 896,701 SH   DFND   677,314 219,387 0
OVID THERAPEUTICS INC COM 690469101   2,037,786 921,457 SH   DFND   790,644 130,813 0
PALISADE BIO INC COM 696389402   1,996,750 1,115,000 SH   DFND   765,000 350,000 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   9,354,403 841,272 SH   DFND   578,886 262,386 0
SAB BIOTHERAPEUTICS INC COM NEW 78397T202   3,886,475 1,012,790 SH   DFND   825,560 187,230 0
SATELLOS BIOSCIENCE INC COM 80401L803   57,116 10,145 SH   DFND   10,145 0 0
TREVI THERAPEUTICS INC COM 89532M101   2,647,064 223,802 SH   DFND   158,390 65,412 0
UNIQURE NV SHS N90064101   1,713,022 104,772 SH   DFND   104,772 0 0
UPSTREAM BIO INC COM 91678A107   3,100,127 341,779 SH   DFND   263,986 77,793 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   4,087,734 210,163 SH   DFND   153,932 56,231 0
VOR BIOPHARMA INC COM NEW 929033207   5,587,368 314,543 SH   DFND   261,033 53,510 0
ZEVRA THERAPEUTICS INC COM NEW 488445206   2,640,798 282,418 SH   DFND   186,172 96,246 0
LEONABIO INC COM 04746L203   1,495,776 149,279 SH   DFND   0 149,279 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207   30,180,379 1,272,360 SH   DFND   0 1,272,360 0