INVENTIVA SA ADS 46124U107 3994612 724678 SH DFND 496755 227923 0 4D MOLECULAR THERAPEUTICS IN COM 35104E100 3581151 380420 SH DFND 309990 70430 0 ABEONA THERAPEUTICS INC COM NEW 00289Y206 6007982 1329899 SH DFND 829557 500342 0 ACHIEVE LIFE SCIENCES INC COM 004468500 11368992 3786425 SH DFND 2601913 1184512 0 ALDEYRA THERAPEUTICS INC COM 01438T106 1234724 730606 SH DFND 730606 0 0 AQUESTIVE THERAPEUTICS INC COM 03843E104 2950600 710988 SH DFND 710988 0 0 ARTIVA BIOTHERAPEUTICS INC COM 04317A107 949818 146369 SH DFND 123139 23230 0 CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 4135129 131364 SH DFND 62370 68994 0 COHERUS ONCOLOGY INC COM 19249H103 2413387 1420550 SH DFND 1167410 253140 0 COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 4117846 742049 SH DFND 582997 159052 0 CONNECT BIOPHARMA HLDGS LTD SHS G23549101 553909 209493 SH DFND 159118 50375 0 CORCEPT THERAPEUTICS INC COM 218352102 6022011 147828 SH DFND 110065 37763 0 CORVUS PHARMACEUTICALS INC COM 221015100 1251074 85791 SH DFND 65549 20242 0 DELCATH SYS INC COM NEW 24661P807 9159490 979698 SH DFND 718572 261126 0 EVOMMUNE INC COM SHS 30054Y107 1279715 55664 SH DFND 55664 0 0 EYEPOINT INC COM NEW 30233G209 2788943 215825 SH DFND 162299 53526 0 IMMUNIC INC COM 4525EP101 2620262 2344779 SH DFND 1905847 438932 0 KALARIS THERAPEUTICS INC COM 482929106 1721024 295771 SH DFND 208345 87426 0 KYVERNA THERAPEUTICS INC COM 501976104 5585588 644421 SH DFND 471315 173106 0 MAZE THERAPEUTICS INC COM 578784100 1307370 43798 SH DFND 43798 0 0 MILESTONE PHARMACEUTICALS IN COM 59935V107 5081571 4118321 SH DFND 2611916 1506405 0 NUVATION BIO INC COM CL A 67080N101 1412680 329296 SH DFND 329296 0 0 OCULAR THERAPEUTIX INC COM 67576A100 3226116 382375 SH DFND 292375 90000 0 OCULIS HOLDING AG ORDINARY SHARES H5870P102 3279243 122223 SH DFND 55556 66667 0 ORCHESTRA BIOMED HLDGS INC COM 68572M106 3830724 896701 SH DFND 677314 219387 0 OVID THERAPEUTICS INC COM 690469101 2037786 921457 SH DFND 790644 130813 0 PALISADE BIO INC COM 696389402 1996750 1115000 SH DFND 765000 350000 0 PHATHOM PHARMACEUTICALS INC COM 71722W107 9354403 841272 SH DFND 578886 262386 0 SAB BIOTHERAPEUTICS INC COM NEW 78397T202 3886475 1012790 SH DFND 825560 187230 0 SATELLOS BIOSCIENCE INC COM 80401L803 57116 10145 SH DFND 10145 0 0 TREVI THERAPEUTICS INC COM 89532M101 2647064 223802 SH DFND 158390 65412 0 UNIQURE NV SHS N90064101 1713022 104772 SH DFND 104772 0 0 UPSTREAM BIO INC COM 91678A107 3100127 341779 SH DFND 263986 77793 0 VIRIDIAN THERAPEUTICS INC COM 92790C104 4087734 210163 SH DFND 153932 56231 0 VOR BIOPHARMA INC COM NEW 929033207 5587368 314543 SH DFND 261033 53510 0 ZEVRA THERAPEUTICS INC COM NEW 488445206 2640798 282418 SH DFND 186172 96246 0 LEONABIO INC COM 04746L203 1495776 149279 SH DFND 0 149279 0 PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 30180379 1272360 SH DFND 0 1272360 0