144 0001969082 XXXXXXXX LIVE 0001628171 REVOLUTION MEDICINES INC 001-39219 700 Saginaw Drive Redwood City CA 94063 6504816801 JEFFREY TODD CISLINI Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

75894 16069416.09 214336418 08/21/2026 NASDAQ Common 06/15/2026 Restricted Stock Units Issuer N 614 06/15/2026 N/A Common 08/21/2026 Exercise of Stock Options Issuer N 75280 08/21/2026 Cash N JEFFREY TODD CISLINI

700 Saginaw Drive Redwood City CA 94063

Common 06/16/2026 2157 336748.90 The 75,280 securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 08/21/2026 05/22/2026 /s/ Jeffrey Todd Cislini