SCHEDULE 13G/A 0001274173-25-000082 0001224962 XXXXXXXX LIVE 2 Common Stock, $0.001 par value per share 04/23/2025 0001966494 CARGO Therapeutics, Inc. 14179K101 835 Industrial Road Suite 400 San Carlos CA 94070 Rule 13d-1(c) Perceptive Advisors LLC DE 0 1170810 0 1170810 1170810 N 2.5 IA Joseph Edelman X1 0 1170810 0 1170810 1170810 N 2.5 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 0 0 0 0 N 0.0 CO Perceptive Xontogeny Venture Fund II, L.P. DE 0 1170810 0 1170810 1170810 N 2.5 PN CARGO Therapeutics, Inc. 835 Industrial Road, Suite 400, San Carlos, CA 94070 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.001 per share (the "Common Stock") of CARGO Therapeutics, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") (iv) Perceptive Xontogeny Venture Fund II, L.P. ("PXV II") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands Corporation. PVX II is a Delaware limited partnership. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover page to this Schedule 13G. The ownership percentages reported are based on 46,052,368 shares of Common Stock outstanding as reported by the Issuer in its Annual Form 10-K filed with the Securities and Exchange Commission on March 12, 2025. Perceptive Advisors: 2.5% Mr. Edelman: 2.5% Master Fund: 0.0% PVX II: 2.5 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 PVX II: 0 Perceptive Advisors: 1,170,810 Shares Mr. Edelman: 1,170,810 Shares Master Fund: 0 Shares PVX II: 1,170,810 Shares Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 PVX II: 0 Perceptive Advisors: 1,170,810 Shares Mr. Edelman: 1,170,810 Shares Master Fund: 0 Shares PVX II: 1,170,810 Shares N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 04/23/2025 Joseph Edelman /s/ Joseph Edelman 04/23/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 04/23/2025 Perceptive Xontogeny Venture Fund II, L.P. /s/ Joseph Edelman 04/23/2025