License and Research and Development Agreements - Additional Information (Details) - USD ($)	1 Months Ended					12 Months Ended
	Nov. 30, 2023	Feb. 28, 2023	Aug. 31, 2022	Jun. 30, 2022	Mar. 31, 2022	Dec. 31, 2023	Dec. 31, 2022
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and development expense						$ 75,791,000	$ 29,373,000
Other non-current liabilities						225,000	250,000
Stanford License
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Upfront payment			$ 50,000
Issuance of common shares for license, shares			67,605
Issuance of common shares for license, fair value			$ 100,000
Research and development expense			200,000			20,000	200,000
Stanford License | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Annual license maintenance fees			100,000
Stanford License | Maximum | Development Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments			4,000,000
Stanford License | Maximum | Sales Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments			$ 7,500,000
Oxford License and Supply Agreement
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Upfront license fee				$ 200,000
Oxford License and Supply Agreement | Development Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and development expense						300,000	200,000
Oxford License and Supply Agreement | Regulatory Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments				1,000,000
Oxford License and Supply Agreement | Commercial Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments				8,000,000
Oxford License and Supply Agreement | Research and Development
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Upfront license fee				200,000
Oxford License and Supply Agreement | Maximum | Development Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments				$ 300,000
2022 NCI License
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment of extension royalty					$ 50,000
Non-refundable license fee					600,000	100,000	200,000
Remaining balance of non refundable license fee						$ 300,000
Accrued non refundable license fee					400,000
Minimum payment on sale, transfer or lease of PRV					5,000,000
Termination and expiration clause						NCI may terminate or modify the 2022 NCI License in the event of an uncured material breach, including, but not limited to, if the Company does not meet certain milestones by certain dates, or upon certain insolvency events that remain uncured following the date that is 90 days following written notice of such breach or insolvency event. The Company may terminate the license, or any portion thereof, at its sole discretion at any time upon 60 days written notice to the NCI.
2022 NCI License | Accrued Expenses and Other Current Liabilities Member
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Accrued non-refundable upfront fees						$ 100,000	100,000
2022 NCI License | Other Noncurrent Liabilities
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Accrued non-refundable upfront fees						200,000	$ 300,000
2022 NCI License | Accrued Clinical and Research and Development Expenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and development expense	$ 300,000
2022 NCI License | Research and Development
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Non-refundable license fee					600,000
2022 NCI License | Minimum Annual Royalty
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and development expense						$ 600,000
2022 NCI License | Maximum | Development Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments					1,800,000
2022 NCI License | Maximum | Regulatory Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments					200,000
2022 NCI License | Maximum | Sales Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments					16,000,000
2022 NCI License | Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Minimum annual royalty payments					50,000
Minimum payment on submission of PRV					$ 500,000
2023 NCI License
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Minimum payment on sale, transfer or lease of PRV		$ 5,000,000
Termination and expiration clause						Unless earlier terminated, the 2023 NCI License will expire upon the expiration of the last to expire licensed patent right. The NCI may terminate or modify the 2023 NCI License in the event of an uncured material breach, including, but not limited to, if the Company does not meet certain milestones by certain dates, or upon certain insolvency events that remain uncured following the date that is 90 days following written notice of such breach or insolvency event. The Company may terminate the license, or any portion thereof, at its sole discretion at any time upon 60 days written notice to the NCI.
Non-refundable license fee		300,000
Payment of reimburse in expense incurred on patent		100,000
Other non-current liabilities						$ 100,000
2023 NCI License | Accrued Clinical and Research and Development Expenses
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and development expense	$ 300,000
2023 NCI License | Research and Development
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Non-refundable license fee		400,000
2023 NCI License | Minimum Annual Royalty
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Research and development expense						$ 400,000
2023 NCI License | Maximum | Development Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments		1,700,000
2023 NCI License | Maximum | Regulatory Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments		100,000
2023 NCI License | Maximum | Sales Milestones
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments		16,000,000
2023 NCI License | Minimum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Minimum annual royalty payments		50,000
Minimum payment on submission of PRV		$ 500,000
Stanford University | Stanford License
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Issuance of common shares for license, shares			22,317
Non-profit Organizations | Stanford License
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Issuance of common shares for license, shares			27,100
Stanford University Inventors | Stanford License
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Issuance of common shares for license, shares			18,188
Commercial Milestone Event | Stanford License | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments			$ 50,000
Certain Additional Milestone Events | Stanford License | Maximum
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Milestone payments			$ 500,000