SCHEDULE 13G/A 0000902664-24-002665 0001975990 XXXXXXXX LIVE 1 Common Stock, par value $0.00001 per share 05/21/2025 0001962918 ACELYRIN, Inc. 00445A100 One Liberty Plaza New York NY 10006 Rule 13d-1(d) AyurMaya Capital Management Company, LP DE 0.00 0.00 0.00 0.00 0.00 N 0 IA PN David E. Goel X1 0.00 0.00 0.00 0.00 0.00 N 0 HC IN ACELYRIN, Inc. 4149 Liberty Canyon Road, Agoura Hills, CA 91301 This statement is filed by: (i) AyurMaya Capital Management Company, LP (the "Investment Manager"), a Delaware limited partnership, and the investment advisor to AyurMaya Capital Management Fund, LP (the "AyurMaya Fund"), with respect to the shares of common stock, par value $0.00001 per share ("Common Stock") of ACELYRIN, Inc. that were directly held by the AyurMaya Fund; and (ii) Mr. David E. Goel ("Mr. Goel"), who serves as the Managing Member of AyurMaya Capital Management Company GP, LLC, the general partner of the Investment Manager, with respect to the shares of Common Stock that were directly held by the AyurMaya Fund. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons". The address of the business office of each of the Reporting Persons is 3 Pleasant Street Portsmouth, Suite 400, NH 03801. The Investment Manager is a Delaware limited partnership. Mr. Goel is a citizen of the United States. Y The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. 0% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. N Y Y Y Y Y Y AyurMaya Capital Management Company, LP /s/ David E. Goel 05/23/2025 David E. Goel /s/ David E. Goel 05/23/2025