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    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

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        <entityName>CASI Pharmaceuticals, Inc.</entityName>
        <issuerAddress>
            <street1>1701-1702, CHINA CENTRAL OFFICE TOWER 1</street1>
            <street2>NO. 81 JIANGUO ROAD, CHAOYANG DISTRICT</street2>
            <city>BEIJING</city>
            <stateOrCountry>F4</stateOrCountry>
            <stateOrCountryDescription>CHINA</stateOrCountryDescription>
            <zipCode>100025</zipCode>
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        <issuerPhoneNumber>86 10 6561 8789</issuerPhoneNumber>
        <jurisdictionOfInc>CAYMAN ISLANDS</jurisdictionOfInc>
        <edgarPreviousNameList>
            <previousName>CASI Pharmaceuticals Holdings, Inc.</previousName>
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        <entityType>Other</entityType>
        <entityTypeOtherDesc>Exempted company incorporated under the laws of the Cayman Islands</entityTypeOtherDesc>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2023</value>
        </yearOfInc>
    </primaryIssuer>

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                <lastName>He</lastName>
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                <firstName>Alexander</firstName>
                <middleName>Y.</middleName>
                <lastName>Wu</lastName>
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                <street1>9620 Medical Center Drive</street1>
                <street2>Suite 300</street2>
                <city>Rockville</city>
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                <stateOrCountryDescription>MARYLAND</stateOrCountryDescription>
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                <lastName>Zeng</lastName>
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                <firstName>Wei</firstName>
                <lastName>Gao</lastName>
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            <relatedPersonRelationshipList>
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            <relationshipClarification>General Counsel</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Kun</firstName>
                <lastName>Qian</lastName>
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                <street1>1701-1702, China Central Office Tower 1</street1>
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            <relatedPersonRelationshipList>
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            <relationshipClarification>Global Controller</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Chunhua</firstName>
                <lastName>Wang</lastName>
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                <stateOrCountryDescription>CHINA</stateOrCountryDescription>
                <zipCode>100025</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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            <relationshipClarification>Chief Operating Officer</relationshipClarification>
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            <relatedPersonName>
                <firstName>Hai</firstName>
                <lastName>Huang</lastName>
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            <relatedPersonRelationshipList>
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            <relationshipClarification>Global Chief Commercial Officer</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Wei (Larry)</firstName>
                <lastName>Zhang</lastName>
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                <street1>601 Gateway Blvd, Suite 1250</street1>
                <city>South San Francisco</city>
                <stateOrCountry>CA</stateOrCountry>
                <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                <zipCode>94080</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Vice President</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alexander</firstName>
                <middleName>A.</middleName>
                <lastName>Zukiwski</lastName>
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            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Medical Officer</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Cory</lastName>
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                <street1>601 Gateway Blvd, Suite 1250</street1>
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                <relationship>Director</relationship>
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            <relationshipClarification>Chief Executive Officer and a member of the Board of Directors</relationshipClarification>
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                <firstName>James</firstName>
                <lastName>Huang</lastName>
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            <relationshipClarification>Non-Executive Chairman of the Board</relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Barbara</firstName>
                <lastName>Krebs-Pohl</lastName>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$5,000,001 - $25,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
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        <typeOfFiling>
            <newOrAmendment>
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            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-02-19</value>
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        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
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        <typesOfSecuritiesOffered>
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            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
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        <businessCombinationTransaction>
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        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>5000000</totalOfferingAmount>
            <totalAmountSold>5000000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
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        <investors>
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            <totalNumberAlreadyInvested>1</totalNumberAlreadyInvested>
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        <salesCommissionsFindersFees>
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                <dollarAmount>0</dollarAmount>
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            <findersFees>
                <dollarAmount>0</dollarAmount>
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                <dollarAmount>0</dollarAmount>
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            <clarificationOfResponse></clarificationOfResponse>
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        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>CASI Pharmaceuticals, Inc.</issuerName>
                <signatureName>/s/ David Cory</signatureName>
                <nameOfSigner>David Cory</nameOfSigner>
                <signatureTitle>CEO</signatureTitle>
                <signatureDate>2026-02-25</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
