<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001956343</cik>
        <entityName>INTRINSIC HEALTH PARTNERS II, L.P.</entityName>
        <issuerAddress>
            <street1>FOUR TOWER BRIDGE, 200 BARR HARBOR DRIVE</street1>
            <street2>SUITE 400</street2>
            <city>WEST CONSHOHOCKEN</city>
            <stateOrCountry>PA</stateOrCountry>
            <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
            <zipCode>19428</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>201.452.7937</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
        </edgarPreviousNameList>
        <entityType>Limited Partnership</entityType>
        <yearOfInc>
            <withinFiveYears>true</withinFiveYears>
            <value>2022</value>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>n/a</firstName>
                <lastName>Intrinsic Health Partners GP II, LLC</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>FOUR TOWER BRIDGE, 200 BARR HARBOR DRIVE</street1>
                <street2>Suite 400</street2>
                <city>WEST CONSHOHOCKEN</city>
                <stateOrCountry>PA</stateOrCountry>
                <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
                <zipCode>19428</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>General Partner of Issuer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Gerald</firstName>
                <middleName>F.</middleName>
                <lastName>Stahlecker III</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>FOUR TOWER BRIDGE, 200 BARR HARBOR DRIVE</street1>
                <street2>Suite 400</street2>
                <city>WEST CONSHOHOCKEN</city>
                <stateOrCountry>PA</stateOrCountry>
                <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
                <zipCode>19428</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Managing Member of Issuer's General Partner</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Howard</firstName>
                <lastName>Goodwin M.D.</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>FOUR TOWER BRIDGE, 200 BARR HARBOR DRIVE</street1>
                <street2>Suite 400</street2>
                <city>WEST CONSHOHOCKEN</city>
                <stateOrCountry>PA</stateOrCountry>
                <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
                <zipCode>19428</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Managing Member of Issuer's General Partner</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Cornelius</firstName>
                <lastName>Merlini</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>FOUR TOWER BRIDGE, 200 BARR HARBOR DRIVE</street1>
                <street2>Suite 400</street2>
                <city>WEST CONSHOHOCKEN</city>
                <stateOrCountry>PA</stateOrCountry>
                <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
                <zipCode>19428</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Managing Member of Issuer's General Partner</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Christopher</firstName>
                <middleName>Edward</middleName>
                <lastName>Jung</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>FOUR TOWER BRIDGE, 200 BARR HARBOR DRIVE</street1>
                <street2>Suite 400</street2>
                <city>WEST CONSHOHOCKEN</city>
                <stateOrCountry>PA</stateOrCountry>
                <stateOrCountryDescription>PENNSYLVANIA</stateOrCountryDescription>
                <zipCode>19428</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Financial Officer of Issuer's General Partner</relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Pooled Investment Fund</industryGroupType>
            <investmentFundInfo>
                <investmentFundType>Venture Capital Fund</investmentFundType>
                <is40Act>false</is40Act>
            </investmentFundInfo>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
            <item>3C</item>
            <item>3C.7</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001956343-24-000001</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2022-12-02</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>true</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isPooledInvestmentFundType>true</isPooledInvestmentFundType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>50000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Cavu Securities LLC</recipientName>
                <recipientCRDNumber>6906</recipientCRDNumber>
                <associatedBDName>Cavu Securities LLC</associatedBDName>
                <associatedBDCRDNumber>6906</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>52 Vanderbuilt Ave</street1>
                    <street2>Suite 403</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10017</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>DE</state>
                    <description>DELAWARE</description>
                    <state>HI</state>
                    <description>HAWAII</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>IA</state>
                    <description>IOWA</description>
                    <state>ME</state>
                    <description>MAINE</description>
                    <state>ID</state>
                    <description>IDAHO</description>
                    <state>MI</state>
                    <description>MICHIGAN</description>
                    <state>UT</state>
                    <description>UTAH</description>
                    <state>MN</state>
                    <description>MINNESOTA</description>
                    <state>MO</state>
                    <description>MISSOURI</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>MS</state>
                    <description>MISSISSIPPI</description>
                    <state>MT</state>
                    <description>MONTANA</description>
                    <state>AK</state>
                    <description>ALASKA</description>
                    <state>AL</state>
                    <description>ALABAMA</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                    <state>AR</state>
                    <description>ARKANSAS</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
                    <state>ND</state>
                    <description>NORTH DAKOTA</description>
                    <state>NE</state>
                    <description>NEBRASKA</description>
                    <state>RI</state>
                    <description>RHODE ISLAND</description>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>NH</state>
                    <description>NEW HAMPSHIRE</description>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                    <state>VT</state>
                    <description>VERMONT</description>
                    <state>NM</state>
                    <description>NEW MEXICO</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NV</state>
                    <description>NEVADA</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>SC</state>
                    <description>SOUTH CAROLINA</description>
                    <state>SD</state>
                    <description>SOUTH DAKOTA</description>
                    <state>WI</state>
                    <description>WISCONSIN</description>
                    <state>OH</state>
                    <description>OHIO</description>
                    <state>GA</state>
                    <description>GEORGIA</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>WV</state>
                    <description>WEST VIRGINIA</description>
                    <state>WY</state>
                    <description>WYOMING</description>
                    <state>OR</state>
                    <description>OREGON</description>
                    <state>KS</state>
                    <description>KANSAS</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>KY</state>
                    <description>KENTUCKY</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                    <state>LA</state>
                    <description>LOUISIANA</description>
                    <state>TN</state>
                    <description>TENNESSEE</description>
                    <state>DC</state>
                    <description>DISTRICT OF COLUMBIA</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>Frontier Solutions, LLC</recipientName>
                <recipientCRDNumber>136102</recipientCRDNumber>
                <associatedBDName>Frontier Solutions, LLC</associatedBDName>
                <associatedBDCRDNumber>136102</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>3307 Church Road</street1>
                    <street2>Suite 220</street2>
                    <city>Richmond</city>
                    <stateOrCountry>VA</stateOrCountry>
                    <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                    <zipCode>23233</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>DE</state>
                    <description>DELAWARE</description>
                    <state>TX</state>
                    <description>TEXAS</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NV</state>
                    <description>NEVADA</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>SC</state>
                    <description>SOUTH CAROLINA</description>
                    <state>SD</state>
                    <description>SOUTH DAKOTA</description>
                    <state>WI</state>
                    <description>WISCONSIN</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>MD</state>
                    <description>MARYLAND</description>
                    <state>IA</state>
                    <description>IOWA</description>
                    <state>OH</state>
                    <description>OHIO</description>
                    <state>GA</state>
                    <description>GEORGIA</description>
                    <state>ID</state>
                    <description>IDAHO</description>
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                    <description>MICHIGAN</description>
                    <state>OK</state>
                    <description>OKLAHOMA</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>UT</state>
                    <description>UTAH</description>
                    <state>WV</state>
                    <description>WEST VIRGINIA</description>
                    <state>MN</state>
                    <description>MINNESOTA</description>
                    <state>MO</state>
                    <description>MISSOURI</description>
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                    <description>ILLINOIS</description>
                    <state>OR</state>
                    <description>OREGON</description>
                    <state>IN</state>
                    <description>INDIANA</description>
                    <state>MT</state>
                    <description>MONTANA</description>
                    <state>KS</state>
                    <description>KANSAS</description>
                    <state>AL</state>
                    <description>ALABAMA</description>
                    <state>VA</state>
                    <description>VIRGINIA</description>
                    <state>CO</state>
                    <description>COLORADO</description>
                    <state>KY</state>
                    <description>KENTUCKY</description>
                    <state>AR</state>
                    <description>ARKANSAS</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>LA</state>
                    <description>LOUISIANA</description>
                    <state>NC</state>
                    <description>NORTH CAROLINA</description>
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                    <description>NEBRASKA</description>
                    <state>RI</state>
                    <description>RHODE ISLAND</description>
                    <state>AZ</state>
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                    <description>NEW HAMPSHIRE</description>
                    <state>TN</state>
                    <description>TENNESSEE</description>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                    <state>VT</state>
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                    <state>NM</state>
                    <description>NEW MEXICO</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>Thomas Herman</recipientName>
                <recipientCRDNumber>2234629</recipientCRDNumber>
                <associatedBDName>Finalis Securities LLC</associatedBDName>
                <associatedBDCRDNumber>305908</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>228 Park Avenue</street1>
                    <street2>Suite 85550</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10003</zipCode>
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                <statesOfSolicitationList>
                    <state>PA</state>
                    <description>PENNSYLVANIA</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
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                    <description>NEW HAMPSHIRE</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>Stonehaven, LLC</recipientName>
                <recipientCRDNumber>118913</recipientCRDNumber>
                <associatedBDName>Stonehaven, LLC</associatedBDName>
                <associatedBDCRDNumber>118913</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>600 Fifth Avenue, 2nd Fl</street1>
                    <street2>600 Fifth Avenue, 2d FL</street2>
                    <city>New York</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10020</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>Butler Capital Investments, LLC</recipientName>
                <recipientCRDNumber>114242</recipientCRDNumber>
                <associatedBDName>Butler Capital Investments, LLC</associatedBDName>
                <associatedBDCRDNumber>114242</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>326 Centre Island Road</street1>
                    <street2>#408</street2>
                    <city>Oyster Bay</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>11771</zipCode>
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                <statesOfSolicitationList>
                    <value>All States</value>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
            <recipient>
                <recipientName>Hollister Associates, LLC</recipientName>
                <recipientCRDNumber>173366</recipientCRDNumber>
                <associatedBDName>Hollister Associates, LLC</associatedBDName>
                <associatedBDCRDNumber>173366</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>257 River Oak Drive</street1>
                    <city>Mount Pleasant</city>
                    <stateOrCountry>SC</stateOrCountry>
                    <stateOrCountryDescription>SOUTH CAROLINA</stateOrCountryDescription>
                    <zipCode>29464</zipCode>
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                <statesOfSolicitationList>
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                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>62374000</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>84</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>139562</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>Amount reported is the amount paid to date.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>INTRINSIC HEALTH PARTNERS II, L.P.</issuerName>
                <signatureName>/s/ Christopher E. Jung</signatureName>
                <nameOfSigner>Christopher E. Jung</nameOfSigner>
                <signatureTitle>Chief Financial Officer of Issuer's General Partner</signatureTitle>
                <signatureDate>2026-07-08</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
