<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001876264</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>2</amendmentNo>
      <securitiesClassTitle>Ordinary Shares, par value CHF 0.01 per share</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/31/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001953530</issuerCik>
        <issuerName>Oculis Holding AG</issuerName>
        <issuerCusips>
          <issuerCusipNumber>H5870P102</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <street1 xmlns="http://www.sec.gov/edgar/common">Bahnhofstrasse 20</street1>
          <city xmlns="http://www.sec.gov/edgar/common">Zug</city>
          <stateOrCountry xmlns="http://www.sec.gov/edgar/common">V8</stateOrCountry>
          <zipCode xmlns="http://www.sec.gov/edgar/common">CH-6300</zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(d)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>LSP 7 Cooperatieve U.A.</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>6950294</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>6950294</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>6950294</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>11.8</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>LSP 7 Management B.V.</reportingPersonName>
      <citizenshipOrOrganization>P7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0</soleVotingPower>
        <sharedVotingPower>6950294</sharedVotingPower>
        <soleDispositivePower>0</soleDispositivePower>
        <sharedDispositivePower>6950294</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>6950294</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>11.8</classPercent>
      <typeOfReportingPerson>OO</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Oculis Holding AG</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>Bahnhofstrasse 20, CH-6300, Zug, Switzerland</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Each of the following is hereinafter individually referred to as a "Reporting Person" and collectively as the "Reporting Persons."  This statement is filed on behalf of:

LSP 7 Cooperatieve U.A. ("LSP 7"); and
LSP 7 Management B.V.
</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>The principal business address of each of the Reporting Persons is c/o EQT Life Sciences, Johannes Vermeerplein 9, 1071 DV Amsterdam, the Netherlands.</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Each of the Reporting Persons is organized under the laws of the Netherlands.</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>The ownership information presented herein represents beneficial ownership of Ordinary Shares of the Issuer as of March 31, 2026, based on 59,034,438 Ordinary Shares outstanding, which consists of (i) 57,984,438 Ordinary Shares outstanding as of December 31, 2025, as disclosed in the Issuer's annual report on Form 20-F filed on March 4, 2026, and (ii) 1,050,000 Ordinary Shares purchased by LSP 7 on March 11, 2026.

LSP 7 is the record holder of 6,950,294 Ordinary Shares.

LSP 7 Management B.V. is the sole director of LSP 7. The managing directors of LSP 7 Management B.V. are Martijn Kleijwegt, Rene Kuijten and Joachim Rothe. As such, LSP 7 Management B.V., Martijn Kleijwegt, Rene Kuijten and Joachim Rothe may be deemed to beneficially own the Ordinary Shares held of record by LSP 7. Each of Mr. Kleijwegt, Mr. Kuijten and Mr. Rothe disclaims beneficial ownership of such shares.</amountBeneficiallyOwned>
        <classPercent>11.8%</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>0</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>6,950,294</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>0</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>6,950,294</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <exhibitInfo>Joint Filing Agreement (previously filed).</exhibitInfo>
    <signatureInformation>
      <reportingPersonName>LSP 7 Cooperatieve U.A.</reportingPersonName>
      <signatureDetails>
        <signature>By: LSP 7 Management B.V., its managing director, /s/ Martijn Kleijwegt</signature>
        <title>Martijn Kleijwegt, Managing Director</title>
        <date>04/29/2026</date>
      </signatureDetails>
      <signatureDetails>
        <signature>By: LSP 7 Management B.V., its managing director, /s/ Rene Kuijten</signature>
        <title>Rene Kuijten, Managing Director</title>
        <date>04/29/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>LSP 7 Management B.V.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Martijn Kleijwegt</signature>
        <title>Martijn Kleijwegt, Managing Director</title>
        <date>04/29/2026</date>
      </signatureDetails>
      <signatureDetails>
        <signature>/s/ Rene Kuijten</signature>
        <title>Rene Kuijten, Managing Director</title>
        <date>04/29/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
