144 0001950232 XXXXXXXX LIVE 0000886163 LIGAND PHARMACEUTICALS INCORPORATED 001-33093 555 Heritage Drive, Suite 200 Jupiter FL 33458 858-550-7500 ANDREW REARDON Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

15000 4303800.00 19935609 09/03/2026 NASDAQ Common 09/03/2026 Exercise of Stock Options Issuer N 5340 09/03/2026 Cash Common 02/15/2025 Restricted Stock Units Issuer N 3336 02/15/2025 N/A Common 02/14/2025 Performance Stock Units Issuer N 6324 02/14/2025 N/A N 10b5-1 Sales for ANDREW REARDON

555 Heritage Drive, Suite 200 Jupiter FL 33458

Common 08/03/2026 5000 1444951.00 10b5-1 Sales for ANDREW REARDON

555 Heritage Drive, Suite 200 Jupiter FL 33458

Common 07/01/2026 5000 1566377.00 The securities to be sold were acquired upon the vesting of restricted stock units during the period of 2/15/2025 through 8/10/2025. The securities to be sold will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment will be the dates of exercise/sale. 09/03/2026 06/04/2026 /s/ Andrew Reardon