144 0001950232 XXXXXXXX LIVE 0000886163 LIGAND PHARMACEUTICALS INCORPORATED 001-33093 555 Heritage Drive, Suite 200 Jupiter FL 33458 858-550-7500 ANDREW REARDON Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

10000 3160900.00 20041061 07/01/2026 NASDAQ Common 07/01/2026 Exercise of Stock Options Issuer N 10000 07/01/2026 Cash N 10b5-1 Sales for ANDREW REARDON

555 Heritage Drive, Suite 200 Jupiter FL 33458

Common 06/01/2026 5000 1135315.50 10b5-1 Sales for ANDREW REARDON

555 Heritage Drive, Suite 200 Jupiter FL 33458

Common 05/01/2026 5000 1156555.50 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 07/01/2026 11/24/2025 /s/ Andrew Reardon