<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2022-10-03</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001367083</issuerCik>
        <issuerName>Sonoma Pharmaceuticals, Inc.</issuerName>
        <issuerTradingSymbol>SNOA</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001949607</rptOwnerCik>
            <rptOwnerName>White Chad Norman</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SONOMA PHARMACEUTICALS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>645 MOLLY LANE, SUITE 150</rptOwnerStreet2>
            <rptOwnerCity>WOODSTOCK</rptOwnerCity>
            <rptOwnerState>GA</rptOwnerState>
            <rptOwnerZipCode>30189</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Interim CFO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock Option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>2.21</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F1"/>
            </exerciseDate>
            <expirationDate>
                <value>2032-10-03</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>5000</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">The Issuer granted the options as an initial grant upon Mr. White's appointment as interim Chief Financial Officer of the Issuer. The options vest in three equal tranches annually on the grant date anniversary, beginning on October 3, 2023 and becoming fully vested on October 3, 2025, or upon change of control of the Issuer.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Chad N. White</signatureName>
        <signatureDate>2022-10-12</signatureDate>
    </ownerSignature>
</ownershipDocument>
