X0508 4 2024-08-05 0001124140 EXACT SCIENCES CORP EXAS 0001941313 Baranick Brian C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 false true false false EVP, GM, Precision Oncology false Common Stock 2024-08-05 4 M false 2712 0.00 A 15991 D Common Stock 2024-08-05 4 F false 1375 55.77 D 14616 D Common Stock 454 I Held in 401(k) Plan Restricted Stock Units 2024-08-05 4 M false 2712 0.00 D Common Stock 2712 0 D Restricted Stock Units 2024-08-05 4 A false 21401 0.00 A Common Stock 21401 21401 D Represents a restricted stock unit award that fully vested on August 5, 2024. In addition to the shares of Common Stock reported on this Form 4, which total 15,070 shares, Mr. Baranick also holds, in the aggregate, an additional 65,007 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Represents shares of Common Stock retained by Exact Sciences Corporation for tax withholding purposes in connection with the net-settlement on the issuance of shares of Common Stock in respect to the vesting of certain restricted stock units on August 5, 2024. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on August 5, 2025. /s/ Brian Baranick by Mark Busch, attorney-in-fact 2024-08-06