The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   3,850 1,000 SH   SOLE   1,000 0 0
4D MOLECULAR THERAPEUTICS IN COM 35104E100   41,980 2,000 SH   SOLE   2,000 0 0
89BIO INC COM 282559103   44,536 5,560 SH   SOLE   5,560 0 0
99 ACQUISITION GROUP INC UNIT 99/99/9999 65445K200   80,550 7,500 SH   SOLE   7,500 0 0
AB ACTIVE ETFS INC ULTRA SHORT INCM 00039J103   505,150 10,000 SH   SOLE   10,000 0 0
ABBOTT LABS COM 002824100   342,903 3,300 SH   SOLE   3,300 0 0
ABEONA THERAPEUTICS INC COM NEW 00289Y206   479,650 113,125 SH   SOLE   113,125 0 0
ABIVAX SA SPONSORED ADS 00370M103   356,940 27,000 SH   SOLE   27,000 0 0
ABSCI CORPORATION COM 00091E109   5,231,469 1,698,529 SH   SOLE   1,698,529 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   21,125 1,300 SH   SOLE   1,300 0 0
ACASTI PHARMA INC CL A 00430K865   2,801,947 959,571 SH   SOLE   959,571 0 0
ACELYRIN INC COM 00445A100   222,798 50,521 SH   SOLE   50,521 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500   2,548,495 542,233 SH   SOLE   542,233 0 0
ACTINIUM PHARMACEUTICALS INC COM 00507W206   555,984 75,133 SH   SOLE   75,133 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J206   7,398 900 SH   SOLE   900 0 0
ADVERUM BIOTECHNOLOGIES INC COM NEW 00773U207   77,518 11,300 SH   SOLE   11,300 0 0
AEROVATE THERAPEUTICS INC COM 008064107   409,914 246,936 SH   SOLE   246,936 0 0
AEROVATE THERAPEUTICS INC COM 008064107   4,150 2,500 SH Call SOLE   0 0 0
AI TRANSN ACQUISITION CORP UNIT 99/99/9999 G01490138   78,750 7,500 SH   SOLE   7,500 0 0
AIMFINITY INVESTMENT CORP I *W EXP 99/99/999 G0135E126   362 18,000 SH   SOLE   18,000 0 0
AKERO THERAPEUTICS INC COM 00973Y108   598,394 25,507 SH   SOLE   25,507 0 0
ALECTOR INC COM 014442107   886,712 195,311 SH   SOLE   195,311 0 0
ALGONQUIN PWR UTILS CORP COM 015857105   87,900 15,000 SH   SOLE   15,000 0 0
ALKERMES PLC SHS G01767105   4,737,506 196,577 SH   SOLE   196,577 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   449,550 1,850 SH   SOLE   1,850 0 0
AMPHASTAR PHARMACEUTICALS IN COM 03209R103   28,000 700 SH   SOLE   700 0 0
AMPLIFY ENERGY CORP NEW COM 03212B103   19,852 2,928 SH   SOLE   2,928 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   203,881 107,306 SH   SOLE   107,306 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   19,000 10,000 SH Call SOLE   0 0 0
ANAPTYSBIO INC COM 032724106   3,904,323 155,799 SH   SOLE   155,799 0 0
ANAPTYSBIO INC COM 032724106   37,590 1,500 SH Call SOLE   0 0 0
ANGIODYNAMICS INC COM 03475V101   870,365 143,862 SH   SOLE   143,862 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   792,134 20,650 SH   SOLE   20,650 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   3,836 100 SH Call SOLE   0 0 0
APOGEE THERAPEUTICS INC COM 03770N101   1,608,431 40,875 SH   SOLE   40,875 0 0
APPLIED THERAPEUTICS INC COM 03828A101   1,497,795 320,727 SH   SOLE   320,727 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100   10,163,813 3,289,260 SH   SOLE   3,289,260 0 0
ARCA BIOPHARMA INC COM 00211Y506   324,309 84,676 SH   SOLE   84,676 0 0
ARCELLX INC COMMON STOCK 03940C100   5,519 100 SH   SOLE   100 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   14,462 1,555 SH   SOLE   1,555 0 0
ARDELYX INC COM 039697107   518,700 70,000 SH   SOLE   70,000 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   153,341 5,900 SH   SOLE   5,900 0 0
ARVINAS INC COM 04335A105   862,488 32,400 SH   SOLE   32,400 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108   613,955 53,527 SH   SOLE   53,527 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   6,991,248 51,263 SH   SOLE   51,263 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   7,799 100 SH   SOLE   100 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   1,257,238 138,158 SH   SOLE   138,158 0 0
AURA BIOSCIENCES INC COM 05153U107   1,536,472 203,237 SH   SOLE   203,237 0 0
AVANGRID INC COM 05351W103   817,190 23,000 SH   SOLE   23,000 0 0
AXSOME THERAPEUTICS INC COM 05464T104   24,150 300 SH   SOLE   300 0 0
BAUSCH PLUS LOMB CORP COMMON SHARES 071705107   92,928 6,400 SH   SOLE   6,400 0 0
BEAM THERAPEUTICS INC COM 07373V105   1,705,704 72,800 SH   SOLE   72,800 0 0
BEIGENE LTD SPONSORED ADR 07725L102   1,583,637 11,100 SH   SOLE   11,100 0 0
BEYOND AIR INC COM 08862L103   658,338 1,225,270 SH   SOLE   1,225,270 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   181,692 29,400 SH   SOLE   29,400 0 0
BLACK HAWK ACQUISITION CORP UNIT 99/99/9999 G1148A127   154,800 15,000 SH   SOLE   15,000 0 0
BLUEBIRD BIO INC COM 09609G100   5,905 6,000 SH   SOLE   6,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   139,499 185,999 SH   SOLE   185,999 0 0
BRIDGEBIO PHARMA INC COM 10806X102   32,031,558 1,264,570 SH   SOLE   1,264,570 0 0
BRIDGEBIO PHARMA INC COM 10806X102   93,721 3,700 SH Call SOLE   0 0 0
BRIDGEBIO PHARMA INC COM 10806X102   30,396 1,200 SH Put SOLE   1,200 0 0
CAPRICOR THERAPEUTICS INC COM NEW 14070B309   97,308 20,400 SH Put SOLE   20,400 0 0
CARA THERAPEUTICS INC COM 140755109   41,143 159,469 SH   SOLE   159,469 0 0
CASI PHARMACEUTICALS INC ORD SHS G1933S101   45,320 8,240 SH   SOLE   8,240 0 0
CELCUITY INC COM 15102K100   22,932 1,400 SH   SOLE   1,400 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   11,214 303 SH   SOLE   303 0 0
CELLECTAR BIOSCIENCES INC COM NEW 15117F807   1,705,235 682,094 SH   SOLE   682,094 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   2,286,369 253,197 SH   SOLE   253,197 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   3,817,082 93,350 SH   SOLE   93,350 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   2,052,678 50,200 SH Put SOLE   50,200 0 0
CETUS CAP ACQUISITION CORP RIGHT 03/31/2024 15719Y121   1,424 4,999 SH   SOLE   4,999 0 0
CETUS CAP ACQUISITION CORP *W EXP 01/31/202 15719Y113   130 5,000 SH   SOLE   5,000 0 0
CG ONCOLOGY INC COM 156944100   405,674 12,850 SH   SOLE   12,850 0 0
CHIMERIX INC COM 16934W106   156,129 178,229 SH   SOLE   178,229 0 0
COGENT COMMUNICATIONS HLDGS COM NEW 19239V302   225,760 4,000 SH   SOLE   4,000 0 0
CONTEXT THERAPEUTICS INC COM 21077P108   1,293,548 645,161 SH   SOLE   645,161 0 0
CORBUS PHARMACEUTICALS HLDGS COM NEW 21833P301   543,000 12,000 SH   SOLE   12,000 0 0
CORTEVA INC COM 22052L104   614,916 11,400 SH   SOLE   11,400 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   3,352,532 74,850 SH   SOLE   74,850 0 0
CULLINAN THERAPEUTICS INC COM 230031106   928,872 53,261 SH   SOLE   53,261 0 0
CYTOKINETICS INC COM NEW 23282W605   46,262,243 853,862 SH   SOLE   853,862 0 0
CYTOKINETICS INC COM NEW 23282W605   5,418 100 SH Call SOLE   0 0 0
CYTOMX THERAPEUTICS INC COM 23284F105   698,047 572,170 SH   SOLE   572,170 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   483,678 35,100 SH   SOLE   35,100 0 0
DELCATH SYS INC COM NEW 24661P807   1,660,164 198,347 SH   SOLE   198,347 0 0
DENALI THERAPEUTICS INC COM 24823R105   882,360 38,000 SH   SOLE   38,000 0 0
EA SERIES TRUST ALPHA ARCH 1-3 02072L565   37,895,032 351,482 SH   SOLE   351,482 0 0
EAGLE PHARMACEUTICALS INC COM 269796108   123,200 22,000 SH   SOLE   22,000 0 0
ECD AUTOMOTIVE DESIGN INC *W EXP 12/12/202 27877D112   652 32,596 SH   SOLE   32,596 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   7,863,310 436,608 SH   SOLE   436,608 0 0
ELEVATION ONCOLOGY INC COM 28623U101   229,303 84,927 SH   SOLE   84,927 0 0
ELIEM THERAPEUTICS INC COM 28658R106   694,611 97,695 SH   SOLE   97,695 0 0
EMBRACE CHANGE ACQUISITN COR RIGHT 10/25/2026 G3034H141   2,484 18,000 SH   SOLE   18,000 0 0
EMBRACE CHANGE ACQUISITN COR *W EXP 10/25/202 G3034H125   378 18,000 SH   SOLE   18,000 0 0
ENDEAVOR GROUP HLDGS INC CL A COM 29260Y109   286,923 10,615 SH   SOLE   10,615 0 0
ENGENE HOLDINGS INC COM 29286M105   5,658 600 SH   SOLE   600 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106   1,059,072 201,728 SH   SOLE   201,728 0 0
EQUILLIUM INC COM 29446K106   97,585 140,775 SH   SOLE   140,775 0 0
EQUILLIUM INC COM 29446K106   6,100 8,800 SH Call SOLE   0 0 0
ERASCA INC COM 29479A108   7,316 3,100 SH   SOLE   3,100 0 0
ETON PHARMACEUTICALS INC COM 29772L108   3,948 1,200 SH   SOLE   1,200 0 0
EVOTEC AG SPONSORED ADS 30050E105   45,120 9,400 SH   SOLE   9,400 0 0
EXACT SCIENCES CORP COM 30063P105   25,350 600 SH   SOLE   600 0 0
FORTE BIOSCIENCES INC COM 34962G109   85,522 159,258 SH   SOLE   159,258 0 0
FOUR LEAF ACQUISITION CORP *W EXP 03/15/202 35088F115   360 7,987 SH   SOLE   7,987 0 0
FULCRUM THERAPEUTICS INC COM 359616109   2,283,888 368,369 SH   SOLE   368,369 0 0
FULCRUM THERAPEUTICS INC COM 359616109   124,000 20,000 SH Call SOLE   0 0 0
FUTURETECH II ACQUISITION CO *W EXP 08/18/202 36119D111   483 30,000 SH   SOLE   30,000 0 0
GERON CORP COM 374163103   381,600 90,000 SH   SOLE   90,000 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   21,571 1,850 SH   SOLE   1,850 0 0
GLOBAL STAR ACQUISITION INC RIGHT 06/21/2024 37962G128   14,800 118,400 SH   SOLE   118,400 0 0
GLOBAL STAR ACQUISITION INC *W EXP 07/15/202 37962G110   2,976 120,000 SH   SOLE   120,000 0 0
GLYCOMIMETICS INC COM 38000Q102   38,016 135,000 SH   SOLE   135,000 0 0
GLYCOMIMETICS INC COM 38000Q102   38,016 135,000 SH Put SOLE   135,000 0 0
GOSSAMER BIO INC COM 38341P102   479,845 532,628 SH   SOLE   532,628 0 0
GOSSAMER BIO INC COM 38341P102   18,018 20,000 SH Call SOLE   0 0 0
GRAIL INC COM 384747101   328,933 21,401 SH   SOLE   21,401 0 0
GREENLIGHT CAPITAL RE LTD CLASS A G4095J109   162,244 12,385 SH   SOLE   12,385 0 0
GUARDANT HEALTH INC COM 40131M109   981,920 34,000 SH   SOLE   34,000 0 0
HELIX ACQUISITION CORP II CL A ORD SHS G4444H101   4,130,290 404,138 SH   SOLE   404,138 0 0
HIMS & HERS HEALTH INC COM CL A 433000106   18,979 940 SH   SOLE   940 0 0
HOWARD HUGHES HOLDINGS INC COM 44267T102   64,820 1,000 SH   SOLE   1,000 0 0
IBIO INC CON NEW 451033708   1,202,700 570,000 SH   SOLE   570,000 0 0
ICHOR HOLDINGS SHS G4740B105   4,163 108 SH   SOLE   108 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   10,533 300 SH   SOLE   300 0 0
IKENA ONCOLOGY INC COM 45175G108   77,030 46,685 SH   SOLE   46,685 0 0
IMMUNOVANT INC COM 45258J102   12,580,735 476,543 SH   SOLE   476,543 0 0
INDIVIOR PLC ORD G4766E116   1,128,513 70,007 SH   SOLE   70,007 0 0
INSMED INC COM PAR $.01 457669307   2,828,539 42,217 SH   SOLE   42,217 0 0
INSMED INC COM PAR $.01 457669307   10,050,000 150,000 SH Call SOLE   0 0 0
INSMED INC COM PAR $.01 457669307   13,453,600 200,800 SH Put SOLE   200,800 0 0
INTELLIGENT BIO SOLUTIONS IN COM 36151G600   207,840 108,250 SH   SOLE   108,250 0 0
INVESCO QQQ TR UNIT SER 1 46090E103   1,437,330 3,000 SH Put SOLE   3,000 0 0
IONIS PHARMACEUTICALS INC COM 462222100   71,490 1,500 SH   SOLE   1,500 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   179,648 22,400 SH   SOLE   22,400 0 0
IRON HORSE ACQUISITIONS CORP UNIT 10/15/2028 462837204   257,250 25,000 SH   SOLE   25,000 0 0
ISHARES TR 20 YR TR BD ETF 464287432   183,560 2,000 SH   SOLE   2,000 0 0
ISHARES TR SHORT TREAS BD 464288679   2,707,250 24,500 SH   SOLE   24,500 0 0
ISHARES TR RUSSELL 2000 ETF 464287655   608,670 3,000 SH Put SOLE   3,000 0 0
ITEOS THERAPEUTICS INC COM 46565G104   890,400 60,000 SH   SOLE   60,000 0 0
J P MORGAN EXCHANGE TRADED F ULTRA SHRT INC 46641Q837   2,725,380 54,000 SH   SOLE   54,000 0 0
JANUX THERAPEUTICS INC COM 47103J105   330,554 7,891 SH   SOLE   7,891 0 0
JVSPAC ACQUISITION CORP UNIT 03/11/2024 G5212E139   312,600 30,000 SH   SOLE   30,000 0 0
KALA BIO INC COM NEW 483119202   2,170,015 306,067 SH   SOLE   306,067 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   141,596 12,020 SH   SOLE   12,020 0 0
KEEN VISION ACQUISITION CORP UNIT 99/99/9999 G52443101   792,750 75,000 SH   SOLE   75,000 0 0
KENSINGTON CAPITAL ACQUISITI SHS CL A G5251K103   94,222 8,500 SH   SOLE   8,500 0 0
KEROS THERAPEUTICS INC COM 492327101   25,085,461 548,916 SH   SOLE   548,916 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   651,899 1,086,498 SH   SOLE   1,086,498 0 0
KINIKSA PHARMACEUTICALS INTL ORD SHS CL A G52694109   2,134,149 114,309 SH   SOLE   114,309 0 0
KIORA PHARMACEUTICALS INC COM 49721T507   724,903 172,596 SH   SOLE   172,596 0 0
KOHLS CORP COM 500255104   45,980 2,000 SH   SOLE   2,000 0 0
KORRO BIO INC COM 500946108   244,203 7,210 SH   SOLE   7,210 0 0
KYMERA THERAPEUTICS INC COM 501575104   1,511,186 50,626 SH   SOLE   50,626 0 0
LEXARIA BIOSCIENCE CORP COM NEW 52886N406   2,627 945 SH   SOLE   945 0 0
LEXEO THERAPEUTICS INC COM 52886X107   20,852 1,300 SH   SOLE   1,300 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504   74,991 890 SH   SOLE   890 0 0
MASIMO CORP COM 574795100   4,786 38 SH   SOLE   38 0 0
MERCK & CO INC COM 58933Y105   9,377,850 75,750 SH   SOLE   75,750 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   199,440 55,400 SH   SOLE   55,400 0 0
MERUS N V COM N5749R100   1,588,714 26,850 SH   SOLE   26,850 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107   267,247 202,460 SH   SOLE   202,460 0 0
MINERALYS THERAPEUTICS INC COM 603170101   296,782 25,366 SH   SOLE   25,366 0 0
MITEK SYS INC COM NEW 606710200   62,608 5,600 SH   SOLE   5,600 0 0
MKS INSTRS INC COM 55306N104   261,160 2,000 SH   SOLE   2,000 0 0
MODERNA INC COM 60770K107   593,750 5,000 SH Call SOLE   0 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   211,056 4,800 SH   SOLE   4,800 0 0
MOVANO INC COM 62459M107   386,925 1,407,000 SH   SOLE   1,407,000 0 0
NCR ATLEOS CORPORATION COM SHS 63001N106   27,020 1,000 SH   SOLE   1,000 0 0
NCR VOYIX CORPORATION COM 62886E108   24,700 2,000 SH   SOLE   2,000 0 0
NEUROGENE INC COM 64135M105   45,597 1,253 SH   SOLE   1,253 0 0
NEXTCURE INC COM 65343E108   141,532 89,014 SH   SOLE   89,014 0 0
NOVO-NORDISK A S ADR 670100205   28,548 200 SH   SOLE   200 0 0
NURIX THERAPEUTICS INC COM 67080M103   73,045 3,500 SH   SOLE   3,500 0 0
NUVEI CORPORATION SUB VTG SHS 67079A102   161,900 5,000 SH   SOLE   5,000 0 0
OAK WOODS ACQUISITION CORP CL A 67190B104   326,400 30,000 SH   SOLE   30,000 0 0
OAK WOODS ACQUISITION CORP RIGHT 03/23/2028 67190B120   7,500 30,000 SH   SOLE   30,000 0 0
OAK WOODS ACQUISITION CORP *W EXP 99/99/999 67190B112   750 30,000 SH   SOLE   30,000 0 0
OCULAR THERAPEUTIX INC COM 67576A100   225,036 32,900 SH   SOLE   32,900 0 0
OKLO INC COM CL A 02156V109   8,470 1,000 SH   SOLE   1,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   217,222 20,076 SH   SOLE   20,076 0 0
OMNIAB INC COM 68218J103   2,672,100 712,560 SH   SOLE   712,560 0 0
OPTINOSE INC COM 68404V100   3,120 3,000 SH   SOLE   3,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201   332,400 12,000 SH   SOLE   12,000 0 0
ORGANON & CO COMMON STOCK 68622V106   51,750 2,500 SH   SOLE   2,500 0 0
OVID THERAPEUTICS INC COM 690469101   14,761 19,190 SH   SOLE   19,190 0 0
PASITHEA THERAPEUTICS CORP COM NEW 70261F202   140,161 27,696 SH   SOLE   27,696 0 0
PERCEPTIVE CAP SOLUTIONS COR CL A ORD SHS G70077105   7,545,000 750,000 SH   SOLE   750,000 0 0
PERRIGO CO PLC SHS G97822103   28,248 1,100 SH   SOLE   1,100 0 0
PERSPECTIVE THERAPEUTICS INC COM NEW 46489V302   697,750 69,985 SH   SOLE   69,985 0 0
PFIZER INC COM 717081103   1,117,801 39,950 SH   SOLE   39,950 0 0
PGIM ETF TR PGIM ULTRA SH BD 69344A107   497,000 10,000 SH   SOLE   10,000 0 0
PHARVARIS N V COM N69605108   37,600 2,000 SH   SOLE   2,000 0 0
PIMCO ETF TR 25YR+ ZERO U S 72201R882   225,270 3,000 SH   SOLE   3,000 0 0
PLIANT THERAPEUTICS INC COM 729139105   107,500 10,000 SH   SOLE   10,000 0 0
PMV PHARMACEUTICALS INC COM 69353Y103   81,000 50,000 SH   SOLE   50,000 0 0
POLYPID LTD COM M8001Q126   446,985 103,950 SH   SOLE   103,950 0 0
PONO CAP TWO INC *W EXP 99/99/999 73245B115   1,406 19,800 SH   SOLE   19,800 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   55,576,244 1,603,932 SH   SOLE   1,603,932 0 0
PROTHENA CORP PLC SHS G72800108   123,592 5,988 SH   SOLE   5,988 0 0
PURETECH HEALTH PLC ADS 746237106   17,500 700 SH   SOLE   700 0 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101   33,100 10,000 SH   SOLE   10,000 0 0
Q32 BIO INC COM 746964105   2,809,247 156,504 SH   SOLE   156,504 0 0
QUINCE THERAPEUTICS INC COM 22053A107   69,718 92,958 SH   SOLE   92,958 0 0
RALLYBIO CORP COM 75120L100   15,008 11,200 SH   SOLE   11,200 0 0
RAPT THERAPEUTICS INC COM 75382E109   22,875 7,500 SH   SOLE   7,500 0 0
REGENXBIO INC COM 75901B107   31,590 2,700 SH   SOLE   2,700 0 0
RELMADA THERAPEUTICS INC COM 75955J402   151,803 50,601 SH   SOLE   50,601 0 0
RENOVORX INC COM NEW 75989R107   401,421 355,240 SH   SOLE   355,240 0 0
REZOLUTE INC COM NEW 76200L309   8,875,037 2,063,962 SH   SOLE   2,063,962 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   533,780 13,000 SH   SOLE   13,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   2,153 100 SH   SOLE   100 0 0
ROIVANT SCIENCES LTD SHS G76279101   43,865,595 4,150,009 SH   SOLE   4,150,009 0 0
ROYALTY PHARMA PLC SHS CLASS A G7709Q104   31,151,725 1,181,332 SH   SOLE   1,181,332 0 0
SANOFI SPONSORED ADR 80105N105   441,532 9,100 SH   SOLE   9,100 0 0
SAREPTA THERAPEUTICS INC COM 803607100   703,100 4,450 SH   SOLE   4,450 0 0
SAVARA INC COM 805111101   2,674,300 663,598 SH   SOLE   663,598 0 0
SAVARA INC COM 805111101   20,150 5,000 SH Call SOLE   0 0 0
SAVARA INC COM 805111101   44,330 11,000 SH Put SOLE   11,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   99,960 12,000 SH   SOLE   12,000 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   765,510 40,290 SH   SOLE   40,290 0 0
SOLENO THERAPEUTICS INC COM 834203309   1,629,103 39,929 SH   SOLE   39,929 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   8,053,793 1,420,422 SH   SOLE   1,420,422 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   4,353,760 8,000 SH Put SOLE   8,000 0 0
SPDR SER TR BLOOMBERG 1-3 MO 78468R663   2,982,850 32,500 SH   SOLE   32,500 0 0
SPERO THERAPEUTICS INC COM 84833T103   1,194,608 918,929 SH   SOLE   918,929 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   183,895 355,216 SH   SOLE   355,216 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   827,082 35,180 SH   SOLE   35,180 0 0
SSGA ACTIVE ETF TR ULT SHT TRM BD 78467V707   1,929,771 47,684 SH   SOLE   47,684 0 0
STEVANATO GROUP S P A ORD SHS T9224W109   495,180 27,000 SH   SOLE   27,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   59,533 1,516 SH   SOLE   1,516 0 0
TARGET HOSPITALITY CORP COM 87615L107   989,682 113,626 SH   SOLE   113,626 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   561,792 250,800 SH   SOLE   250,800 0 0
TECTONIC THERAPEUTIC INC COM 878972108   5,877,781 356,878 SH   SOLE   356,878 0 0
TERNS PHARMACEUTICALS INC COM 880881107   102,150 15,000 SH   SOLE   15,000 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209   1,675,716 103,121 SH   SOLE   103,121 0 0
TG THERAPEUTICS INC COM 88322Q108   99,428 5,589 SH   SOLE   5,589 0 0
THERAPEUTICSMD INC COM NEW 88338N206   434,958 270,160 SH   SOLE   270,160 0 0
THUNDER PWR HLDGS INC COM 31561T102   2,475 1,500 SH   SOLE   1,500 0 0
TMT ACQUISITION CORP SHS G89229119   549,000 50,000 SH   SOLE   50,000 0 0
TMT ACQUISITION CORP RIGHT 03/27/2028 G89229135   17,016 49,900 SH   SOLE   49,900 0 0
TOURMALINE BIO INC COM 89157D105   270,832 21,060 SH   SOLE   21,060 0 0
TRIPADVISOR INC COM 896945201   391,820 22,000 SH   SOLE   22,000 0 0
TYRA BIOSCIENCES INC COM 90240B106   4,797 300 SH   SOLE   300 0 0
ULTRA CLEAN HLDGS INC COM 90385V107   49,000 1,000 SH   SOLE   1,000 0 0
UNIQURE NV SHS N90064101   5,477,588 1,222,676 SH   SOLE   1,222,676 0 0
VANGUARD BD INDEX FDS VANGUARD ULTRA 92203C303   2,733,801 55,206 SH   SOLE   55,206 0 0
VAXART INC COM NEW 92243A200   630,978 945,568 SH   SOLE   945,568 0 0
VAXCYTE INC COM 92243G108   924,998 12,250 SH   SOLE   12,250 0 0
VENTYX BIOSCIENCES INC COM 92332V107   29,926 12,955 SH   SOLE   12,955 0 0
VERA THERAPEUTICS INC CL A 92337R101   39,038 1,079 SH   SOLE   1,079 0 0
VERVE THERAPEUTICS INC COM 92539P101   214,720 44,000 SH   SOLE   44,000 0 0
VIKING THERAPEUTICS INC COM 92686J106   4,835,943 91,227 SH   SOLE   91,227 0 0
VIR BIOTECHNOLOGY INC COM 92764N102   979,000 110,000 SH   SOLE   110,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   104,080 8,000 SH   SOLE   8,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106   147,395 18,634 SH   SOLE   18,634 0 0
VYNE THERAPEUTICS INC COM 92941V308   337,297 171,217 SH   SOLE   171,217 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   382,488 76,651 SH   SOLE   76,651 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105   293,157 890 SH   SOLE   890 0 0
WISDOMTREE TR FLOATNG RAT TREA 97717Y527   2,666,430 53,000 SH   SOLE   53,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105   183,253 4,700 SH   SOLE   4,700 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103   2,250 1,000 SH   SOLE   1,000 0 0
XILIO THERAPEUTICS INC COM 98422T100   1,421 1,500 SH   SOLE   1,500 0 0
ZAI LAB LTD ADR 98887Q104   381,260 22,000 SH   SOLE   22,000 0 0
ZEVRA THERAPEUTICS INC COM NEW 488445206   9,800 2,000 SH   SOLE   2,000 0 0
ZYVERSA THERAPEUTICS INC COM 98987D300   36,088 9,598 SH   SOLE   9,598 0 0