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                          March 15, 2024

       Quang Pham
       President, Chief Executive Officer and Director
       Cadrenal Therapeutics, Inc.
       822 A1A North, Suite 306
       Ponte Vedra, Florida 32082

                                                        Re: Cadrenal
Therapeutics, Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed March 12,
2024
                                                            File No. 333-277835

       Dear Quang Pham:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Chris
Edwards at 202-551-6761 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Leslie Marlow, Esq.