The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMARIN CORP PLC SPONS ADR NEW 023111206   385,200 256,800 SH   SOLE NONE 256,800 0 0
ARGENX SE SPONSORED ADR 04016X101   13,563,402 36,404 SH   SOLE NONE 36,404 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   7,101,129 102,307 SH   SOLE NONE 102,307 0 0
BIONTECH SE SPONSORED ADS 09075V102   4,622,544 37,108 SH   SOLE NONE 37,108 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   241,100 5,000 SH   SOLE NONE 5,000 0 0
NOVO-NORDISK A S ADR 670100205   51,092,693 321,055 SH   SOLE NONE 321,055 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   1,816,256 90,451 SH   SOLE NONE 90,451 0 0
ABBVIE INC COM 00287Y109   14,474,143 90,821 SH   SOLE NONE 90,821 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   3,199,311 15,971 SH   SOLE NONE 15,971 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   244,666 8,339 SH   SOLE NONE 8,339 0 0
BIOGEN INC COM 09062X103   22,242,400 80,000 SH   SOLE NONE 80,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   11,519,537 118,465 SH   SOLE NONE 118,465 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   1,476,095 169,277 SH   SOLE NONE 169,277 0 0
CHARLES RIV LABS INTL INC COM 159864107   1,393,567 6,905 SH   SOLE NONE 6,905 0 0
FIBROGEN INC COM 31572Q808   966,495 51,795 SH   SOLE NONE 51,795 0 0
IVERIC BIO INC COM 46583P102   9,844,283 404,615 SH   SOLE NONE 404,615 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   2,252,640 41,600 SH   SOLE NONE 41,600 0 0
KARUNA THERAPEUTICS INC COM 48576A100   16,135,263 88,831 SH   SOLE NONE 88,831 0 0
LILLY ELI & CO COM 532457108   9,247,614 26,928 SH   SOLE NONE 26,928 0 0
LARIMAR THERAPEUTICS INC COM 517125100   172,398 38,057 SH   SOLE NONE 38,057 0 0
MERCK & CO INC COM 58933Y105   35,023,588 329,200 SH   SOLE NONE 329,200 0 0
MODERNA INC COM 60770K107   13,011,144 84,719 SH   SOLE NONE 84,719 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   4,554,900 45,000 SH   SOLE NONE 45,000 0 0
VAXCYTE INC COM 92243G108   853,007 22,759 SH   SOLE NONE 22,759 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   3,636,800 40,000 SH   SOLE NONE 40,000 0 0
ROIVANT SCIENCES LTD SHS G76279101   1,164,291 157,763 SH   SOLE NONE 157,763 0 0
SEAGEN INC COM 81181C104   10,361,402 51,175 SH   SOLE NONE 51,175 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   2,932,571 5,088 SH   SOLE NONE 5,088 0 0
TYRA BIOSCIENCES INC COM 90240B106   727,216 45,253 SH   SOLE NONE 45,253 0 0
VIKING THERAPEUTICS INC COM 92686J106   1,138,993 68,408 SH   SOLE NONE 68,408 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   2,241,408 7,114 SH   SOLE NONE 7,114 0 0
WATERS CORP COM 941848103   880,897 2,845 SH   SOLE NONE 2,845 0 0
ALTIMMUNE INC CALL 02155H900   422,000 100,000 SH Call SOLE NONE 100,000 0 0
KARUNA THERAPEUTICS INC PUT 48576A950   5,449,200 30,000 SH Put SOLE NONE 30,000 0 0
NOVO-NORDISK A S CALL 670100905   7,957,000 50,000 SH Call SOLE NONE 50,000 0 0
SAREPTA THERAPEUTICS INC CALL 803607900   8,269,800 60,000 SH Call SOLE NONE 60,000 0 0