144 0001971973 XXXXXXXX LIVE 0001937653 Zymeworks Inc. 001-41535 108 Patriot Drive Suite A Middletown DE 19709 302-274-8744 Derek John Michael Miller Former Director Common Stock Morgan Stanley Smith Barney

1 New York Plaza, 38th Floor. New York NY 10004

118000 2810760 74836534 11/24/2025 Nasdaq Common Stock 11/24/2025 Exercise of options Issuer N 118000 11/24/2025 Exercise and sell to cover Y 11/24/2025 /s/ Derek John Michael Miller