Exhibit 3.4

BRITISH COLUMBIA BC Registry Servies Mailing Address: PO Box 9431 Stn Prov Govt Victoria BC V8W 9V3 www.corporateonline.gov.bc.ca Location: 2nd Floor - 940 Blanshard Street Victoria BC 1 877 526-1526 Notice of Articles BUSINESS CORPORATIONS ACT CERTIFIED COPY Of a Document filed with the Province of British Columbia Registrar of Companies T.K. SPARKS This Notice of Articles was issued by the Registrar on: June 10, 2022 01:32 PM Pacific Time Incorporation Number: C1117210 Recognition Date and Time: Continued into British Columbia on May 2, 2017 09:30 AM Pacific Time NOTICE OF ARTICLES Name of Company: ZYMEWORKS INC. REGISTERED OFFICE INFORMATION Mailing Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA Delivery Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA RECORDS OFFICE INFORMATION Mailing Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA Delivery Address: SUITE 2600, THREE BENTALL CENTRE 595 BURRARD STREET, P.O. BOX 49314 VANCOUVER BC V7X 1L3 CANADA Page: 1 of 3

DIRECTOR INFORMATION Last Name, First Name, Middle Name: Cox, Troy Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Last Name, First Name, Middle Name: Sacks, Natalie Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Last Name, First Name, Middle Name: Zoth, Lota Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Last Name, First Name, Middle Name: Galbraith, Kenneth Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Last Name, First Name, Middle Name: Renton, Hollings C, Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Last Name, First Name, Middle Name: Mahony, Susan Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Page: 2 of 3

Last Name, First Name, Middle Name: Neu, Kelvin Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Last Name, First Name, Middle Name: Hillan, Kenneth J. Mailing Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA Delivery Address: 114 EAST 4TH AVENUE, SUITE 800 VANCOUVER BC V5T 1G4 CANADA RESOLUTION DATES: Date(s) of Resolution(s) or Court Order(s) attaching or altering Special Rights and Restrictions attached to a class or a series of shares: June 9, 2022 AUTHORIZED SHARE STRUCTURE 1. No Maximum Common Shares Without Par Value Without Special Rights or Restrictions attached 2. No Maximum Preferred Shares Without Par Value With Special Rights or Restrictions attached 1. No Maximum Series A Participating Preferred Special Rights or Restrictions are attached Page: 3 of 3