X0306 4 2022-12-21 0 0001937653 Zymeworks Inc. ZYME 0001278219 Zoth Lota S. C/O ZYMEWORKS INC. 108 PATRIOT DRIVE, SUITE A MIDDLETOWN DE 19709 1 0 0 0 Stock Option (Right to Buy) 8.75 2022-12-21 4 A 0 25000 0.00 A 2032-12-20 Common Stock 25000 25000 D Stock options vest on date of next annual general meeting following grant date of December 21, 2022. Exhibit List - Exhibit 24 - Power of Attorney On October 13, 2022, the Issuer (formerly Zymeworks Delaware Inc., a Delaware corporation) became the successor issuer of Zymeworks BC Inc. (formerly Zymeworks Inc., a corporation continued under the Business Corporations Act (British Columbia)) pursuant to Rule 12g-3 of the Securities Exchange Act of 1934, as amended. On such date the Issuer completed a series of transactions, including a redomicile, pursuant to a statutory plan of arrangement under Section 288 of the Business Corporations Act (British Columbia), as a result of which common shares of Zymeworks BC Inc. were exchanged for either shares of common stock of the Issuer or exchangeable shares issued by Zymeworks ExchangeCo Ltd., an indirect subsidiary of the Issuer. /s/ Daniel Dex, Attorney-in-Fact 2022-12-23