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Pay vs Performance Disclosure - USD ($)
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Pay vs Performance Disclosure    
Pay vs Performance Disclosure, Table
Pay Versus Performance
In accordance with rules adopted by the SEC pursuant to the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010, we provide the following disclosure regarding the relationship between Company performance and the “compensation actually paid” to our principal executive officer (“PEO”) and other NEOs (the “Non-PEO NEOs”) for the fiscal years listed below. The Compensation Committee did not consider the pay versus performance disclosure below in making its pay decisions for any of the years shown.
 
Year
   
Summary
Compensation
Table Total
for PEO
1

($)
     
Compensation
Actually Paid
to PEO
1, 2

($)
     
Average
Summary
Compensation
Table Total

for Non-PEO
NEOs
1

($)
     
Average
Compensation
Actually Paid
to

Non-PEO
NEOs
1,2

($)
     
Value of Initial
Fixed $100
Investment based
on:
3
     
Net
Income
($ Millions)
  
  
TSR
($)
     
Peer
Group
TSR
($)
  
2024
      6,469,297        49,549,373        2,588,362        13,170,066        235.78        104.00        (242 ) 
2023
      5,805,558        4,717,541        3,265,820        3,318,816        102.48        104.59        (177 ) 
 
1.
Michael Davidson, M.D. was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below.
 
2023
   
2024
Ian Somaiya
    Ian Somaiya
John Kastelein, M.D., Ph.D. FESC
    John Kastelein, M.D., Ph.D. FESC
   Juliette Audet
   Douglas Kling
 
2.
Calculated in accordance with Item 402(v) of Regulation S-K and does not reflect compensation realized by the Company’s NEOs in either of the years presented. Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs from the Summary Compensation Table as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718.
 
Year
   
Summary
Compensation
Table Total for
PEO
($)
     
Exclusion of
Stock Awards
for PEO
($)
     
Inclusion of
Equity Values
for PEO

($)
     
Compensation
Actually Paid to
PEO
($)
  
2024
      6,469,297        (5,347,060 )       48,427,136        49,549,373  
2023
      5,805,558        (4,923,558 )       3,835,541        4,717,541  
 
Year
   
Average
Summary
Compensation
Table Total for
Non-PEO NEOs

($)
     
Average
Exclusion of
Stock Awards
for Non-PEO
NEOs
($)
     
Average
Inclusion of
Equity Values
for Non-PEO
NEOs
($)
     
Average
Compensation
Actually Paid
to Non-PEO
NEOs
($)
  
2024
      2,588,362        (1,812,416 )       12,394,121        13,170,066  
2023
      3,265,820        (2,861,653 )       2,914,648        3,318,816  
 
Amounts in the columns entitled “Exclusion of Stock Awards for PEO” and “Average Exclusion of Stock Awards for Non-PEO NEOs” are the totals from the “Option Awards” column of the Summary Compensation Table. Amounts in the columns entitled “Inclusion of Equity Values for PEO” and “Average Inclusion of Equity Values for Non-PEO NEOs” in the tables above were calculated as follows:
 
Year
   
Year-End
Fair Value of
Outstanding
and Unvested
Equity
Awards
Granted
During Year
for PEO
($)
     
Year-over-
Year Change
in Fair Value
of
Outstanding
and Unvested
Equity
Awards
Granted in
Prior Years
for PEO
($)
    
Vesting-Date

Fair Value of
Equity
Awards
Granted and
Vested
During Year
for PEO
($)
     
Year-over-
Year Change
in Fair Value
of Unvested
Equity
Awards
Granted in
Prior Year
that Vested
During Year
for PEO
($)
     
Year-End
Fair Value of
Equity
Awards that
Failed to
Meet Vesting
Conditions
During Year
for PEO
($)
     
Value of
Dividends or
Other
Earnings
Paid on
Equity
Awards Not
Otherwise
Reflected for
PEO
($)
     
Total Equity
Award
Adjustments
for PEO
($)
  
2024
      18,036,059        22,714,096       —         7,676,981        —         —         48,427,136  
2023
      4,060,090        (403,427 )      —         178,878        —         —         3,835,541  
 
Year
   
Average
Year-End
Fair Value of
Outstanding
and Unvested
Equity
Awards
Granted
During Year
r for Non-
PEO NEOs
($)
     
Average
Year-over-
year Change
in Fair Value
of
Outstanding
and Unvested
Equity
Awards
Granted in
Prior Years
for Non-PEO
NEOs
($)
    
Average
Vesting-Date

Fair Value of
Equity
Awards
Granted and
Vested
During Year
for Non-PEO

NEOs
($)
     
Average
Year-over-
Year Change
in Fair Value
of Unvested
Equity
Awards
Granted in
Prior Year
that Vested
During Year
for Non-PEO

NEOs
($)
    
Average
Year-End
Fair Value of
Equity
Awards that
Failed to
Meet Vesting
Conditions
During Year
for Non-PEO

NEOs
($)
     
Average
Value of
Dividends or
Other
Earnings
Paid on
Equity
Awards Not
Otherwise
Reflected for
Non-PEO
NEOs
($)
     
Total
Average
Equity
Award
Adjustments
for Non-PEO

NEOs ($)
  
2024
      4,683,173        6,005,580       —         1,705,368       —         —         12,394,121  
2023
      3,005,046        (88,047 )      —         (2,351 )      —         —         2,914,648  
 
3.
The Peer Group Total Shareholder Return (“TSR”) set forth in this table utilizes the Nasdaq Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2024. The comparison assumes $100 was invested for the period starting December 31, 2022, through the end of the listed year in the Company and in the Nasdaq Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.
 
Named Executive Officers, Footnote
1.
Michael Davidson, M.D. was our PEO for each year presented. The individuals comprising the Non-PEO NEOs for each year presented are listed below.
 
2023
   
2024
Ian Somaiya
    Ian Somaiya
John Kastelein, M.D., Ph.D. FESC
    John Kastelein, M.D., Ph.D. FESC
   Juliette Audet
   Douglas Kling
  
Peer Group Issuers, Footnote The Peer Group Total Shareholder Return (“TSR”) set forth in this table utilizes the Nasdaq Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2024. The comparison assumes $100 was invested for the period starting December 31, 2022, through the end of the listed year in the Company and in the Nasdaq Biotechnology Index, respectively. Historical stock performance is not necessarily indicative of future stock performance.  
PEO Total Compensation Amount $ 6,469,297 $ 5,805,558
PEO Actually Paid Compensation Amount $ 49,549,373 4,717,541
Adjustment To PEO Compensation, Footnote
2.
Calculated in accordance with Item 402(v) of Regulation S-K and does not reflect compensation realized by the Company’s NEOs in either of the years presented. Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs from the Summary Compensation Table as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718.
 
Year
   
Summary
Compensation
Table Total for
PEO
($)
     
Exclusion of
Stock Awards
for PEO
($)
     
Inclusion of
Equity Values
for PEO

($)
     
Compensation
Actually Paid to
PEO
($)
  
2024
      6,469,297        (5,347,060 )       48,427,136        49,549,373  
2023
      5,805,558        (4,923,558 )       3,835,541        4,717,541  
 
Year
   
Average
Summary
Compensation
Table Total for
Non-PEO NEOs

($)
     
Average
Exclusion of
Stock Awards
for Non-PEO
NEOs
($)
     
Average
Inclusion of
Equity Values
for Non-PEO
NEOs
($)
     
Average
Compensation
Actually Paid
to Non-PEO
NEOs
($)
  
2024
      2,588,362        (1,812,416 )       12,394,121        13,170,066  
2023
      3,265,820        (2,861,653 )       2,914,648        3,318,816  
 
Amounts in the columns entitled “Exclusion of Stock Awards for PEO” and “Average Exclusion of Stock Awards for Non-PEO NEOs” are the totals from the “Option Awards” column of the Summary Compensation Table. Amounts in the columns entitled “Inclusion of Equity Values for PEO” and “Average Inclusion of Equity Values for Non-PEO NEOs” in the tables above were calculated as follows:
 
Year
   
Year-End
Fair Value of
Outstanding
and Unvested
Equity
Awards
Granted
During Year
for PEO
($)
     
Year-over-
Year Change
in Fair Value
of
Outstanding
and Unvested
Equity
Awards
Granted in
Prior Years
for PEO
($)
    
Vesting-Date

Fair Value of
Equity
Awards
Granted and
Vested
During Year
for PEO
($)
     
Year-over-
Year Change
in Fair Value
of Unvested
Equity
Awards
Granted in
Prior Year
that Vested
During Year
for PEO
($)
     
Year-End
Fair Value of
Equity
Awards that
Failed to
Meet Vesting
Conditions
During Year
for PEO
($)
     
Value of
Dividends or
Other
Earnings
Paid on
Equity
Awards Not
Otherwise
Reflected for
PEO
($)
     
Total Equity
Award
Adjustments
for PEO
($)
  
2024
      18,036,059        22,714,096       —         7,676,981        —         —         48,427,136  
2023
      4,060,090        (403,427 )      —         178,878        —         —         3,835,541  
 
Year
   
Average
Year-End
Fair Value of
Outstanding
and Unvested
Equity
Awards
Granted
During Year
r for Non-
PEO NEOs
($)
     
Average
Year-over-
year Change
in Fair Value
of
Outstanding
and Unvested
Equity
Awards
Granted in
Prior Years
for Non-PEO
NEOs
($)
    
Average
Vesting-Date

Fair Value of
Equity
Awards
Granted and
Vested
During Year
for Non-PEO

NEOs
($)
     
Average
Year-over-
Year Change
in Fair Value
of Unvested
Equity
Awards
Granted in
Prior Year
that Vested
During Year
for Non-PEO

NEOs
($)
    
Average
Year-End
Fair Value of
Equity
Awards that
Failed to
Meet Vesting
Conditions
During Year
for Non-PEO

NEOs
($)
     
Average
Value of
Dividends or
Other
Earnings
Paid on
Equity
Awards Not
Otherwise
Reflected for
Non-PEO
NEOs
($)
     
Total
Average
Equity
Award
Adjustments
for Non-PEO

NEOs ($)
  
2024
      4,683,173        6,005,580       —         1,705,368       —         —         12,394,121  
2023
      3,005,046        (88,047 )      —         (2,351 )      —         —         2,914,648  
  
Non-PEO NEO Average Total Compensation Amount $ 2,588,362 3,265,820
Non-PEO NEO Average Compensation Actually Paid Amount $ 13,170,066 3,318,816
Adjustment to Non-PEO NEO Compensation Footnote
2.
Calculated in accordance with Item 402(v) of Regulation S-K and does not reflect compensation realized by the Company’s NEOs in either of the years presented. Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEO and the Non-PEO NEOs from the Summary Compensation Table as set forth below. Equity values are calculated in accordance with FASB ASC Topic 718.
 
Year
   
Summary
Compensation
Table Total for
PEO
($)
     
Exclusion of
Stock Awards
for PEO
($)
     
Inclusion of
Equity Values
for PEO

($)
     
Compensation
Actually Paid to
PEO
($)
  
2024
      6,469,297        (5,347,060 )       48,427,136        49,549,373  
2023
      5,805,558        (4,923,558 )       3,835,541        4,717,541  
 
Year
   
Average
Summary
Compensation
Table Total for
Non-PEO NEOs

($)
     
Average
Exclusion of
Stock Awards
for Non-PEO
NEOs
($)
     
Average
Inclusion of
Equity Values
for Non-PEO
NEOs
($)
     
Average
Compensation
Actually Paid
to Non-PEO
NEOs
($)
  
2024
      2,588,362        (1,812,416 )       12,394,121        13,170,066  
2023
      3,265,820        (2,861,653 )       2,914,648        3,318,816  
 
Amounts in the columns entitled “Exclusion of Stock Awards for PEO” and “Average Exclusion of Stock Awards for Non-PEO NEOs” are the totals from the “Option Awards” column of the Summary Compensation Table. Amounts in the columns entitled “Inclusion of Equity Values for PEO” and “Average Inclusion of Equity Values for Non-PEO NEOs” in the tables above were calculated as follows:
 
Year
   
Year-End
Fair Value of
Outstanding
and Unvested
Equity
Awards
Granted
During Year
for PEO
($)
     
Year-over-
Year Change
in Fair Value
of
Outstanding
and Unvested
Equity
Awards
Granted in
Prior Years
for PEO
($)
    
Vesting-Date

Fair Value of
Equity
Awards
Granted and
Vested
During Year
for PEO
($)
     
Year-over-
Year Change
in Fair Value
of Unvested
Equity
Awards
Granted in
Prior Year
that Vested
During Year
for PEO
($)
     
Year-End
Fair Value of
Equity
Awards that
Failed to
Meet Vesting
Conditions
During Year
for PEO
($)
     
Value of
Dividends or
Other
Earnings
Paid on
Equity
Awards Not
Otherwise
Reflected for
PEO
($)
     
Total Equity
Award
Adjustments
for PEO
($)
  
2024
      18,036,059        22,714,096       —         7,676,981        —         —         48,427,136  
2023
      4,060,090        (403,427 )      —         178,878        —         —         3,835,541  
 
Year
   
Average
Year-End
Fair Value of
Outstanding
and Unvested
Equity
Awards
Granted
During Year
r for Non-
PEO NEOs
($)
     
Average
Year-over-
year Change
in Fair Value
of
Outstanding
and Unvested
Equity
Awards
Granted in
Prior Years
for Non-PEO
NEOs
($)
    
Average
Vesting-Date

Fair Value of
Equity
Awards
Granted and
Vested
During Year
for Non-PEO

NEOs
($)
     
Average
Year-over-
Year Change
in Fair Value
of Unvested
Equity
Awards
Granted in
Prior Year
that Vested
During Year
for Non-PEO

NEOs
($)
    
Average
Year-End
Fair Value of
Equity
Awards that
Failed to
Meet Vesting
Conditions
During Year
for Non-PEO

NEOs
($)
     
Average
Value of
Dividends or
Other
Earnings
Paid on
Equity
Awards Not
Otherwise
Reflected for
Non-PEO
NEOs
($)
     
Total
Average
Equity
Award
Adjustments
for Non-PEO

NEOs ($)
  
2024
      4,683,173        6,005,580       —         1,705,368       —         —         12,394,121  
2023
      3,005,046        (88,047 )      —         (2,351 )      —         —         2,914,648  
  
Compensation Actually Paid vs. Total Shareholder Return
Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and TSR
The following chart sets forth the relationship between
Compensation
Actually Paid to our PEO, the average of Compensation Actually
Paid
to our Non-PEO NEOs, and the cumulative
TSR over
the two most recently completed fiscal years for the Company and the Nasdaq Biotechnology Index, our selected peer group.
 
 
LOGO
 
Compensation Actually Paid vs. Net Income
Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and Net Income
The following chart sets forth the relationship between Compensation Actually Paid to our PEO, the average of Compensation Actually Paid to our Non-PEO NEOs, and our net income
during
the
two most
recently completed fiscal years.
 
 
LOGO
 
  
Total Shareholder Return Vs Peer Group
Relationship Between PEO and Non-PEO NEO Compensation Actually Paid and TSR
The following chart sets forth the relationship between
Compensation
Actually Paid to our PEO, the average of Compensation Actually
Paid
to our Non-PEO NEOs, and the cumulative
TSR over
the two most recently completed fiscal years for the Company and the Nasdaq Biotechnology Index, our selected peer group.
 
 
LOGO
 
Total Shareholder Return Amount $ 235.78 102.48
Peer Group Total Shareholder Return Amount 104 104.59
Net Income (Loss) $ (242,000,000) $ (177,000,000)
PEO Name Michael Davidson, M.D. Michael Davidson, M.D.
PEO | Equity Awards Adjustments    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount $ 48,427,136 $ 3,835,541
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 18,036,059 4,060,090
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 22,714,096 (403,427)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 0 0
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 7,676,981 178,878
PEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 0 0
PEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 0 0
PEO | Exclusionof StockAwards [Member]    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount (5,347,060) (4,923,558)
Non-PEO NEO | Equity Awards Adjustments    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 12,394,121 2,914,648
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 4,683,173 3,005,046
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 6,005,580 (88,047)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 0 0
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 1,705,368 (2,351)
Non-PEO NEO | Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 0 0
Non-PEO NEO | Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount 0 0
Non-PEO NEO | Exclusionof StockAwards [Member]    
Pay vs Performance Disclosure    
Adjustment to Compensation, Amount $ (1,812,416) $ (2,861,653)