Shareholders' Equity - Changes in Shareholders' Deficit (Details) - USD ($) $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2025	Jun. 30, 2025	Mar. 31, 2025	Sep. 30, 2024	Jun. 30, 2024	Mar. 31, 2024	Sep. 30, 2025	Sep. 30, 2024
Beginning balance			$ 423,436				$ 423,436
Net loss	$ (173,443)			$ (160,304)			(593,267)	$ (659,579)
Ending balance	$ (17,160)						$ (17,160)
Common Shares
Beginning balance (in shares)	105,782,447	102,104,024	101,221,989	92,346,332	81,807,221	81,115,723	101,221,989	81,115,723
Beginning balance	$ 1,743,109	$ 1,689,346	$ 1,656,702	$ 1,298,553	$ 910,964	$ 887,528	$ 1,656,702	$ 887,528
Obligation to issue common shares as payment under license and other agreements (in shares)			222,119
Obligation to issue common shares as payment under license and other agreements			$ 8,554
Issuance of common shares as payment under license and other agreements (in shares)		3,588,688	132,700	154	1,872,874	97,233
Issuance of common shares as payment under license and other agreements		$ 51,426	$ 4,844	$ 9	$ 65,981	$ 5,637
Issuance of common shares under equity incentive plan (shares)	21,208		527,216	397,422		351,307
Issuance of common shares under 2022 Equity Incentive Plan	$ 631		$ 19,246	$ 6,758		$ 7,452
Issuance of common shares under equity incentive plan and employee share purchase plan (in shares)		89,735			110,834
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan		$ 2,337			$ 3,442
Issuance of common shares as payment for IPR&D asset (in shares)				428	10,452	242,958
Issuance of common shares as payment for IPR&D asset				$ 18	$ 446	$ 10,347
Issuance of common shares, net of offering costs (in shares)				2,154,857	8,544,951
Issuance of common shares, net of offering costs				$ 76,361	$ 317,720
Ending balance (in shares)	105,803,655	105,782,447	102,104,024	94,899,193	92,346,332	81,807,221	105,803,655	94,899,193
Ending balance	$ 1,743,740	$ 1,743,109	$ 1,689,346	$ 1,381,699	$ 1,298,553	$ 910,964	$ 1,743,740	$ 1,381,699
Additional Paid-in Capital
Beginning balance	157,019	137,467	112,369	83,832	69,385	39,804	112,369	39,804
Obligation to issue common shares as payment under license and other agreements			(8,554)
Issuance of common shares under 2022 Equity Incentive Plan	(509)		(19,410)	(2,954)		(5,296)
Non-cash share-based compensation expense	21,535	20,812	53,062	12,160	12,232	34,877
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan		(1,260)			(1,125)
Issuance of warrant as payment under license agreement					3,340
Ending balance	178,045	157,019	137,467	93,038	83,832	69,385	178,045	93,038
Accumulated Deficit
Beginning balance	(1,765,538)	(1,567,391)	(1,345,714)	(998,567)	(678,796)	(499,292)	(1,345,714)	(499,292)
Net loss	(173,443)	(198,147)	(221,677)	(160,304)	(319,771)	(179,504)
Ending balance	(1,938,981)	(1,765,538)	(1,567,391)	(1,158,871)	(998,567)	(678,796)	(1,938,981)	(1,158,871)
Accumulated other comprehensive income
Beginning balance	(3)	73	79	(78)	(106)	(65)	79	(65)
Other comprehensive income (loss)	39	(76)	(6)	218	28	(41)	(43)	205
Ending balance	36	(3)	73	140	(78)	(106)	36	140
Total Shareholders' Equity (Deficit)
Beginning balance	134,587	259,495	423,436	383,740	301,447	427,975	423,436	427,975
Net loss	(173,443)	(198,147)	(221,677)	(160,304)	(319,771)	(179,504)
Obligation to issue common shares as payment under license and other agreements			0
Issuance of common shares as payment under license and other agreements		51,426	4,844	9	65,981	5,637
Issuance of common shares under 2022 Equity Incentive Plan	122		(164)	3,804		2,156
Non-cash share-based compensation expense	21,535	20,812	53,062	12,160	12,232	34,877
Other comprehensive income (loss)	39	(76)	(6)	218	28	(41)
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan		1,077			2,317
Issuance of common shares as payment for IPR&D asset				18	446	10,347
Issuance of common shares, net of offering costs				76,361	317,720
Issuance of warrant as payment under license agreement					3,340
Ending balance	$ (17,160)	$ 134,587	$ 259,495	$ 316,006	$ 383,740	$ 301,447	$ (17,160)	$ 316,006