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License, Acquisitions and Other Agreements - Taldefgrobep Alfa License Agreement (Details) - USD ($)
3 Months Ended 6 Months Ended
Jun. 30, 2025
Jun. 30, 2024
Jun. 30, 2025
Jun. 30, 2024
License and other agreements        
Milestone payment to be paid upon regulatory achievement $ 701,975,000   $ 701,975,000  
Research and development 184,367,000 $ 314,819,000 371,951,000 $ 470,791,000
BMS        
License and other agreements        
Research and development 0 $ 0 0 $ 0
BMS | Taldefgrobep Alfa License Agreement        
License and other agreements        
Milestone payment to be paid upon regulatory achievement $ 200,000,000   $ 200,000,000