License, Acquisitions and Other Agreements - ALS Biopharma Agreement (Details)	1 Months Ended	3 Months Ended		6 Months Ended
	Aug. 31, 2015 claim prodrug	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)	Jun. 30, 2025 USD ($)	Jun. 30, 2024 USD ($)
License and other agreements
Milestone payment to be paid upon regulatory achievement		$ 701,975,000		$ 701,975,000
Research and development		184,367,000	$ 314,819,000	371,951,000	$ 470,791,000
ALS Biopharma Agreement | Collaborative arrangement
License and other agreements
Number of prodrugs of glutamate modulating agents | prodrug	300
Milestone payment to be paid upon regulatory achievement		4,000,000		4,000,000
Number of claims | claim	1
Research and development		$ 0	$ 0	$ 0	$ 0