Shareholders' Equity (Tables)

6 Months Ended

Jun. 30, 2025

Stockholders' Equity Note [Abstract]

Schedule of changes in shareholders' equity (deficit)

Changes in shareholders’ equity for the three and six months ended June 30, 2025 and 2024 were as follows:

	Common Shares
	Shares	Amount		Additional Paid-in Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)		Total Shareholders' Equity
Balances as of December 31, 2024	101,221,989	$	1,656,702	$	112,369	$	(1,345,714)	$	79	$	423,436
Net loss	—	—		—		(221,677)		—		(221,677)
Obligation to issue common shares as payment under license and other agreements	222,119	8,554		(8,554)		—		—		—
Issuance of common shares as payment under license and other agreements	132,700	4,844		—		—		—		4,844
Issuance of common shares under 2022 Equity Incentive Plan	527,216	19,246		(19,410)		—		—		(164)
Non-cash share-based compensation expense	—	—		53,062		—		—		53,062
Other comprehensive loss	—	—		—		—		(6)		(6)
Balances as of March 31, 2025	102,104,024	$	1,689,346	$	137,467	$	(1,567,391)	$	73	$	259,495
Net loss	—	—		—		(198,147)		—		(198,147)
Issuance of common shares as payment under license and other agreements	3,588,688	51,426		—		—		—		51,426
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan	89,735	2,337		(1,260)		—		—		1,077
Non-cash share-based compensation expense	—	—		20,812		—		—		20,812
Other comprehensive loss	—	—		—		—		(76)		(76)
Balances as of June 30, 2025	105,782,447	$	1,743,109	$	157,019	$	(1,765,538)	$	(3)	$	134,587

	Common Shares
	Shares	Amount		Additional Paid-in Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)		Total Shareholders' Equity
Balances as of December 31, 2023	81,115,723	$	887,528	$	39,804	$	(499,292)	$	(65)	$	427,975
Net loss	—	—		—		(179,504)		—		(179,504)
Issuance of common shares as payment for IPR&D asset	242,958	10,347		—		—		—		10,347
Issuance of common shares as payment for license and other agreements	97,233	5,637		—		—		—		5,637
Issuance of common shares under 2022 Equity Incentive Plan	351,307	7,452		(5,296)		—		—		2,156
Non-cash share-based compensation expense	—	—		34,877		—		—		34,877
Other comprehensive loss	—	—		—		—		(41)		(41)
Balances as of March 31, 2024	81,807,221	$	910,964	$	69,385	$	(678,796)	$	(106)	$	301,447
Net loss	—	—		—		(319,771)		—		(319,771)
Issuance of common shares, net of offering costs	8,544,951	317,720		—		—		—		317,720
Issuance of common shares as payment for acquisition of IPR&D asset	10,452	446		—		—		—		446
Issuance of common shares as payment under license and other agreements	1,872,874	65,981		—		—		—		65,981
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan	110,834	3,442		(1,125)		—		—		2,317
Issuance of warrant as payment under license agreement	—	—		3,340		—		—		3,340
Non-cash share-based compensation expense	—	—		12,232		—		—		12,232
Other comprehensive income	—	—		—		—		28		28
Balance as of June 30, 2024	92,346,332	$	1,298,553	$	83,832	$	(998,567)	$	(78)	$	383,740