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Non-Cash Share-Based Compensation (Tables)
 3 Months Ended
Mar. 31, 2025
Share-Based Payment Arrangement [Abstract]  
Schedule of non-cash share-based compensation expense Non-cash share-based compensation expense, consisting of expense for share options, restricted share units ("RSUs"), performance share options, and the Employee Share Purchase Plan ("ESPP"), was classified in the condensed consolidated statements of operations and comprehensive loss as follows:

Three Months Ended March 31,
20252024
Research and development expenses
$35,233 $21,291 
General and administrative expenses
17,829 13,586 
Total non-cash share-based compensation expense$53,062 $34,877 
As of March 31, 2025, total unrecognized compensation cost related to the unvested share-based awards was $154,832, which is expected to be recognized over a weighted average period of 1.80 years.
Schedule of stock option activity
The following table is a summary of the Company's share option activity for the three months ended March 31, 2025:
 
Number of
Shares
Weighted
Average
Exercise
Price
Weighted
Average
Remaining
Contractual
Term
Aggregate
Intrinsic
Value
 (in years)
Outstanding as of December 31, 2024
12,781,084$17.46 
Granted2,726,375$38.53 
Exercised(55,365)$7.37 
Forfeited(17,724)$37.70 
Outstanding as of March 31, 2025
15,434,370$21.20 8.27$136,819 
Options exercisable as of March 31, 2025
8,852,922$16.86 8.00$99,101 
Vested and expected to vest as of March 31, 2025
15,434,370$21.20 8.27$136,819 
Schedule of RSU activity
The following table is a summary of the RSU activity for the three months ended March 31, 2025:
Number of shares
Weighted Average Grant Date Fair Value
Unvested as of December 31, 2024
277,221 $41.87 
Granted
1,622,375 $38.58 
Forfeited
(2,749)$39.69 
Vested
(489,746)$39.23 
Unvested as of March 31, 2025
1,407,101 $39.00