Shareholders' Equity (Tables)

3 Months Ended

Mar. 31, 2025

Stockholders' Equity Note [Abstract]

Schedule of changes in shareholders' equity (deficit)

Changes in shareholders’ equity for the three months ended March 31, 2025 and 2024 were as follows:

	Common Shares
	Shares	Amount		Additional Paid-in Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)		Total Shareholders' Equity
Balances as of December 31, 2024	101,221,989	$	1,656,702	$	112,369	$	(1,345,714)	$	79	$	423,436
Net loss	—	—		—		(221,677)		—		(221,677)
Obligation to issue common shares as payment under license and other agreements	222,119	8,554		(8,554)		—		—		—
Issuance of common shares as payment under license and other agreements	132,700	4,844		—		—		—		4,844
Issuance of common shares under 2022 Equity Incentive Plan	527,216	19,246		(19,410)		—		—		(164)
Non-cash share-based compensation expense	—	—		53,062		—		—		53,062
Other comprehensive loss	—	—		—		—		(6)		(6)
Balances as of March 31, 2025	102,104,024	$	1,689,346	$	137,467	$	(1,567,391)	$	73	$	259,495

	Common Shares
	Shares	Amount		Additional Paid-in Capital		Accumulated Deficit		Accumulated Other Comprehensive Income (Loss)		Total Shareholders' Equity
Balances as of December 31, 2023	81,115,723	$	887,528	$	39,804	$	(499,292)	$	(65)	$	427,975
Net loss	—	—		—		(179,504)		—		(179,504)
Issuance of common shares as payment for IPR&D asset	242,958	10,347		—		—		—		10,347
Issuance of common shares as payment for license and other agreements	97,233	5,637		—		—		—		5,637
Issuance of common shares under 2022 Equity Incentive Plan	351,307	7,452		(5,296)		—		—		2,156
Non-cash share-based compensation expense	—	—		34,877		—		—		34,877
Other comprehensive loss	—	—		—		—		(41)		(41)
Balances as of March 31, 2024	81,807,221	910,964		69,385		(678,796)		(106)		301,447