Commitments and Contingencies - Narrative (Details)		12 Months Ended
	Jan. 01, 2021	Dec. 31, 2024 USD ($) lease	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Mar. 31, 2024 term
Other Commitments [Line Items]
Operating lease cost		$ 5,884,000	$ 5,874,000	$ 1,158,000
Short-term lease agreements | lease		1
Operating cash flows paid for operating leases		$ 5,114,000	4,854,000	780,000
Development milestone payment to be paid		170,538,000
Milestone payment to be paid upon regulatory achievement		701,975,000
Milestone payment to be paid upon commercial achievement		3,185,450,000
Research and development		795,871,000	$ 373,281,000	$ 437,072,000
Research and Development Arrangement
Other Commitments [Line Items]
Research commitments		0
Moda Pharmaceuticals LLC
Other Commitments [Line Items]
Research and development		2,125,000
Moda Pharmaceuticals LLC | Moda Agreement
Other Commitments [Line Items]
Initial term of agreement (in years)	4 years
Development milestone payment to be paid		31,245,000
Milestone payment to be paid upon regulatory achievement		22,000,000
Milestone payment to be paid upon commercial achievement		$ 104,612,000
Pittsburgh Centre Avenue Lease Agreement
Other Commitments [Line Items]
Lease agreement, term					122 months
Number of additional periods | term					1
Extension term (in months)					60 months
Minimum
Other Commitments [Line Items]
Lease agreement, term		1 year
Option to extend, term		5 years
Minimum | Pittsburgh Centre Avenue Lease Agreement
Other Commitments [Line Items]
Annual commitments		$ 1,859,000
Maximum
Other Commitments [Line Items]
Lease agreement, term		10 years
Option to extend, term		10 years
Maximum | Pittsburgh Centre Avenue Lease Agreement
Other Commitments [Line Items]
Annual commitments		$ 2,373,000