License, Acquisitions and Other Agreements - Acquisitions (Details) - USD ($) $ / shares in Units, $ in Thousands				1 Months Ended		3 Months Ended	12 Months Ended
	May 03, 2024	May 01, 2024	Jan. 07, 2024	May 31, 2024	Dec. 31, 2023	Mar. 31, 2024	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
License agreements
Success-based milestone payments, based on regulatory approval							$ 185,000
Additional regulatory milestone payments							60,000
Common stock issued (shares)					721,136
Issuance of common shares, net of offering costs					$ 21,814		664,015	$ 242,425	$ 282,804
Pyramid
License agreements
Upfront payment of common shares, shares (in shares)			255,794,000
Upfront payment of common shares, value			$ 10,894
R&D expense						$ 5,689
Common shares issuable (in shares)						98,129
Pyramid | Developmental And Regulatory Milestones, First Asset | Lead Asset
License agreements
Success-based payments							5,000
Pyramid | Developmental And Regulatory Milestones, Second Asset | Second Asset
License agreements
Success-based payments							30,000
Pyramid | Commercial Sales-Based Milestones
License agreements
Success-based payments							40,000
Purchase Agreement, Knopp Amendment
License agreements
Number of securities called by warrants (shares)		294,195
Exercise price of warrants (in dollars per share)		$ 67.98
Forward Contracts
License agreements
Forward contract, current	$ 75,220
Derivative Liability, 2024 Additional Consideration | Level 3
License agreements
Change in fair value of forward contract and derivative liability in other income, net							(9,239)
2024 Additional Consideration True-up | Level 3
License agreements
Change in fair value of forward contract and derivative liability in other income, net							$ (15,540)
Fair value	15,540
Forward Contract Liability, 2025 Addtional Consideration
License agreements
Fair value first anniversary of execution period							60 days
Common shares issuable, value							$ 75,000
Forward Contract Liability, 2025 Addtional Consideration | Level 3
License agreements
Change in fair value of forward contract and derivative liability in other income, net							7,560
Fair value		$ 63,940
2025 Additional Consideration True-up | Level 3
License agreements
Change in fair value of forward contract and derivative liability in other income, net							$ (600)
Fair value	$ 13,810
Purchase Agreement, Knopp Amendment
License agreements
Issuance of common shares, net of offering costs		$ 75,000
Fair value first anniversary of execution period		60 days
Purchase Agreement, Knopp Amendment, 2025 Additional Consideration
License agreements
Fair value first anniversary of execution period	60 days
Common shares issuable, value	$ 75,000
Purchase Agreement, Knopp Amendment
License agreements
Common stock issued (shares)				1,872,874
Issuance of common shares, net of offering costs				$ 65,981