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Non-Cash Share-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2024
Share-Based Payment Arrangement [Abstract]  
Schedule of non-cash share-based compensation expense Non-cash share-based compensation expense, consisting of expense for share options, restricted share units ("RSUs"), performance share options, and the Employee Share Purchase Plan ("ESPP"), was classified in the condensed consolidated statements of operations and comprehensive loss as follows:

Three Months Ended September 30,Nine Months Ended September 30,
2024202320242023
Research and development expenses
$7,164 $2,184 $35,526 $6,882 
General and administrative expenses
4,996 2,272 23,743 6,034 
Total non-cash share-based compensation expense$12,160 $4,456 $59,269 $12,916 
Schedule of stock option activity
The following table is a summary of the Company's share option activity for the nine months ended September 30, 2024:
 
Number of
Shares
Weighted
Average
Exercise
Price
Weighted
Average
Remaining
Contractual
Term
Aggregate
Intrinsic
Value
 (in years)
Outstanding as of December 31, 2023
11,379,429$11.48 
Granted2,503,161$42.04 
Exercised(684,124)$9.49 
Forfeited(104,448)$20.53 
Outstanding as of September 30, 2024
13,094,018$17.36 8.44$427,203 
Options exercisable as of September 30, 2024
5,192,055$13.72 8.30$188,273 
Vested and expected to vest as of September 30, 2024
13,094,018$17.36 8.44$427,203 
Schedule of RSU activity
The following table is a summary of the RSU activity for the nine months ended September 30, 2024:
Number of shares
Weighted Average Grant Date Fair Value
Unvested as of December 31, 2023
— $— 
Granted
381,011 $41.88 
Forfeited
(6,045)$41.93 
Vested
(95,309)$41.88 
Unvested as of September 30, 2024
279,657 $41.87