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License Agreements - Moda Pharmaceuticals LLC (Details) - USD ($)
3 Months Ended
Jan. 01, 2021
Mar. 31, 2023
Mar. 31, 2022
License and other agreements      
Research and development   $ 63,461,000 $ 70,096,000
Moda Pharmaceuticals LLC      
License and other agreements      
Research and development   $ 0 $ 0
Moda Pharmaceuticals LLC | Moda Agreement      
License and other agreements      
Eligible development milestone payments $ 81,612,000    
Eligible commercial milestone payments $ 30,171,000    
Initial term of agreement (in years) 4 years    
Moda Pharmaceuticals LLC | Moda Agreement | License agreement      
License and other agreements      
Payment for license agreement $ 2,700,000    
Issuance of common shares as payment for assets (in shares) 37,836    
Issuance of common shares as payment for assets $ 3,243,000