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License Agreements - Fox Chase Chemical Diversity Center Agreement (Details) - USD ($)
1 Months Ended 3 Months Ended
May 31, 2019
Mar. 31, 2023
Dec. 31, 2022
Mar. 31, 2022
Nov. 30, 2020
License and other agreements          
Development milestone payment to be paid   $ 125,125,000      
Research and development   63,461,000   $ 70,096,000  
FCCDC Agreement          
License and other agreements          
Research and development   $ 0   $ 0  
FCCDC Agreement | Collaborative arrangement          
License and other agreements          
Common stock issued (shares) 100,000        
Issuance of common shares, net of offering costs $ 5,646,000        
Development milestone payment to be paid 3,000,000        
Development milestone payments to be paid per each additional NDA filing $ 1,000,000        
FCCDC Agreement | Collaborative arrangement | Minimum          
License and other agreements          
Earned royalty payment per agreement (percent)         0.00%
FCCDC Agreement | Collaborative arrangement | Maximum          
License and other agreements          
Earned royalty payment per agreement (percent)         10.00%
FCCDC Warrants          
License and other agreements          
Number of securities called by warrants (shares) 100,000        
Exercise price of warrants (in dollars per share) $ 56.46        
Research and development     $ 4,245,000