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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

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The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill.

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The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 912
-SubTopic 730
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Number of shares of stock issued during the period as part of a transaction to acquire assets that do not qualify as a business combination.

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Value of shares of stock issued during the period as part of a transaction to acquire assets that do not qualify as a business combination.

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License Agreements - KU Leuven (Details) - USD ($)	1 Months Ended	3 Months Ended		9 Months Ended
License Agreements - KU Leuven (Details) - USD ($)	Jan. 31, 2022	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
License and other agreements
Research and development		$ 52,845,000	$ 46,973,000	$ 300,028,000	$ 139,668,000
KU Leuven Agreement
License and other agreements
Research and development		$ 0	$ 0	$ 0	$ 0
KU Leuven \| KU Leuven Agreement
License and other agreements
Development, regulatory and commercialization milestone payments	$ 327,750,000
KU Leuven \| License agreement \| KU Leuven Agreement
License and other agreements
Payment for license agreement	$ 3,000,000
Issuance of common shares as payment for assets (in shares)	15,340
Issuance of common shares as payment for assets	$ 1,779,000