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License Agreements - UCONN (Details) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2022
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
License and other agreements          
Research and development   $ 52,845,000 $ 46,973,000 $ 300,028,000 $ 139,668,000
UCONN          
License and other agreements          
Research and development   $ 0 $ 0 $ 0 $ 0
UCONN Agreement | UCONN          
License and other agreements          
Milestone payment to be paid upon developmental and regulatory achievement $ 30,100,000        
Commercial milestone payment to be paid 50,000,000        
UCONN Agreement | UCONN | License agreement          
License and other agreements          
Payment for license agreement $ 400,000