Share-Based Compensation - Non-Cash Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Share-Based Compensation
Total non-cash share-based compensation expense	$ 16,997	$ 15,393	$ 77,927	$ 52,671
Research and development expenses
Share-Based Compensation
Total non-cash share-based compensation expense	9,722	10,187	46,976	32,085
General and administrative expenses
Share-Based Compensation
Total non-cash share-based compensation expense	$ 7,275	$ 5,206	$ 30,951	$ 20,586