<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001672659</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001933414</issuerCik>
      <issuerName>Mineralys Therapeutics, Inc.</issuerName>
      <secFileNumber>001-41614</secFileNumber>
      <issuerAddress>
        <com:street1>150 N. RADNOR CHESTER RD.</com:street1>
        <com:street2>SUITE F200</com:street2>
        <com:city>RADNOR</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19087</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(888) 378-6240</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Rodman David Malcom</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>225 Liberty St</com:street1>
          <com:street2>Floor 37</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10281</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6348</noOfUnitsSold>
      <aggregateMarketValue>175585.68</aggregateMarketValue>
      <noOfUnitsOutstanding>82399478</noOfUnitsOutstanding>
      <approxSaleDate>04/15/2026</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common stock</securitiesClassTitle>
      <acquiredDate>04/14/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Exercise of employee stock options</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Mineralys Therapeutics, Inc.</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>6348</amountOfSecuritiesAcquired>
      <paymentDate>04/14/2025</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common stock</securitiesClassTitle>
      <saleDate>01/09/2026</saleDate>
      <amountOfSecuritiesSold>2170</amountOfSecuritiesSold>
      <grossProceeds>72195.90</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common stock</securitiesClassTitle>
      <saleDate>01/12/2026</saleDate>
      <amountOfSecuritiesSold>6348</amountOfSecuritiesSold>
      <grossProceeds>205142.99</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common stock</securitiesClassTitle>
      <saleDate>01/13/2026</saleDate>
      <amountOfSecuritiesSold>7709</amountOfSecuritiesSold>
      <grossProceeds>252469.75</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common stock</securitiesClassTitle>
      <saleDate>01/14/2026</saleDate>
      <amountOfSecuritiesSold>11367</amountOfSecuritiesSold>
      <grossProceeds>370645.39</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>01/20/2026</saleDate>
      <amountOfSecuritiesSold>416</amountOfSecuritiesSold>
      <grossProceeds>13353.60</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>02/09/2026</saleDate>
      <amountOfSecuritiesSold>2171</amountOfSecuritiesSold>
      <grossProceeds>65585.91</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>02/12/2026</saleDate>
      <amountOfSecuritiesSold>6349</amountOfSecuritiesSold>
      <grossProceeds>184076.52</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>02/16/2026</saleDate>
      <amountOfSecuritiesSold>14055</amountOfSecuritiesSold>
      <grossProceeds>385732.29</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>02/17/2026</saleDate>
      <amountOfSecuritiesSold>417</amountOfSecuritiesSold>
      <grossProceeds>11505.03</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>03/09/2026</saleDate>
      <amountOfSecuritiesSold>2171</amountOfSecuritiesSold>
      <grossProceeds>58269.64</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>03/12/2026</saleDate>
      <amountOfSecuritiesSold>6348</amountOfSecuritiesSold>
      <grossProceeds>173748.15</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>03/13/2026</saleDate>
      <amountOfSecuritiesSold>14058</amountOfSecuritiesSold>
      <grossProceeds>369225.07</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>03/17/2026</saleDate>
      <amountOfSecuritiesSold>417</amountOfSecuritiesSold>
      <grossProceeds>10696.05</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/09/2026</saleDate>
      <amountOfSecuritiesSold>2170</amountOfSecuritiesSold>
      <grossProceeds>59414.60</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>David Rodman</name>
        <address>
          <com:street1>150 N. RADNOR CHESTER ROAD</com:street1>
          <com:street2>SUITE F200</com:street2>
          <com:city>RADNOR</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/13/2026</saleDate>
      <amountOfSecuritiesSold>14058</amountOfSecuritiesSold>
      <grossProceeds>373086.81</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>04/15/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>09/29/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>David Rodman</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
