144 0001672659 XXXXXXXX LIVE 0001933414 Mineralys Therapeutics, Inc. 001-41614 150 N. RADNOR CHESTER RD. SUITE F200 RADNOR PA 19087 (888) 378-6240 Rodman David Malcom Officer Common stock Merrill Lynch

225 Liberty St Floor 37 New York NY 10281

2170 72195.90 79139956 01/09/2026 NASDAQ Common stock 01/09/2026 Exercise of employee stock options Mineralys Therapeutics, Inc. N 2170 01/09/2026 Broker assisted cashless exercise N David Rodman

150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087

Common stock 10/15/2025 10369 445982.61 David Rodman

150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087

Common stock 01/05/2026 192715 6749100.06 David Rodman

150 N. RADNOR CHESTER ROAD SUITE F200 RADNOR PA 19087

Common stock 01/02/2026 70037 2511919.03 01/09/2026 09/29/2025 David Rodman