SCHEDULE 13G/A 0001746274 XXXXXXXX LIVE 3 Common Stock, par value $0.0001 per share 12/31/2025 0001933414 Mineralys Therapeutics, Inc. 603170101 150 N. Radnor Chester Rd Suite F200 Radnor PA 19087 Rule 13d-1(d) Catalys Pacific Fund, LP E9 0 8002738 0 8002738 8002738 N 10.1 PN Catalys Pacific Fund GP, LP E9 0 8002738 0 8002738 8002738 N 10.1 PN Catalys Pacific, LLC E9 0 8002738 0 8002738 8002738 N 10.1 OO Brian Taylor Slingsby X1 0 8002738 0 8002738 8002738 N 10.1 IN Mineralys Therapeutics, Inc. 150 N. Radnor Chester Rd, Suite F200, Radnor, PA 19087 Each of the following is hereinafter individually referred to as a "Reporting Person" and collectively as the "Reporting Persons." This statement is filed on behalf of: Catalys Pacific Fund, LP Catalys Pacific Fund GP, LP Catalys Pacific, LLC Brian Taylor Slingsby The principal business address for Catalys Pacific Fund, LP, Catalys Pacific Fund GP, LP and Catalys Pacific, LLC is IQ EQ Corporate Services (Cayman) Limited, 3rd Floor Whitehall House, 238 North Church Street, Grand Cayman, Cayman Islands. The principal business address for Brian Taylor Slingsby is 1700 Westlake Avenue N, Suite 200, Thinkspace, Seattle, WA 98109. Brian Taylor Slingsby is a citizen of the United States. The other Reporting Persons are each entities organized under the laws of the Cayman Islands. Y The ownership information presented below represents beneficial ownership of Common Stock of the Issuer as of December 31, 2025, based upon 79,139,956 shares of Common Stock outstanding as of November 3, 2025, as disclosed in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 10, 2025. Catalys Pacific Fund, LP is the beneficial owner of 8,002,738 shares of Common Stock, which includes 7,903,838 shares of Common Stock held of record by Catalys Pacific Fund, LP and 98,900 shares of Common Stock underlying stock options that are exercisable within 60 days of December 31, 2025. Catalys Pacific Fund GP, LP is the general partner of Catalys Pacific Fund, LP. Catalys Pacific, LLC is the general partner of Catalys Pacific Fund GP, LP. Brian Taylor Slingsby is the managing director of Catalys Pacific, LLC. As a result, each of the Reporting Persons may be deemed to share beneficial ownership over the securities reported herein. 10.1% 0 8,002,738 0 8,002,738 Y Y Y Y Y Y Catalys Pacific Fund, LP By: Catalys Pacific Fund GP, LP, its General Partner, By: Catalys Pacific, LLC, its General Partner, By: /s/ Brian Taylor Slingsby 02/13/2026 Catalys Pacific Fund GP, LP By: Catalys Pacific, LLC, its General Partner, By: /s/ Brian Taylor Slingsby 02/13/2026 Catalys Pacific, LLC /s/ Brian Taylor Slingsby 02/13/2026 Brian Taylor Slingsby /s/ Brian Taylor Slingsby 02/13/2026