X0306 4 2022-12-13 0 0001374339 ProMIS Neurosciences Inc. PMN 0001927062 Kirwin Patrick D. C/O PROMIS NEUROSCIENCES INC. SUITE 200, 1920 YONGE STREET TORONTO A6 M4S 3E2 ONTARIO, CANADA 1 0 0 0 Common Shares 2022-12-13 4 P 0 1000 4.87 A 25998 I By Patrick D. Kirwin Professional Corp Common Shares 2022-12-15 4 P 0 2000 4.51 A 27998 I By Patrick D. Kirwin Professional Corp Common Shares 41983 D Common Shares 2383 I By Patrick Kirwin TFSA Common Shares 5732 I By his spouse The purchase price of CAD$6.60 has been converted to USD based on the WSJ exchange rate on December 13, 2022 of CAD$1.00=US$0.7383 The purchase price of CAD$6.16 has been converted to USD based on the WSJ exchange rate on December 15, 2022 of CAD$1.00=US$0.7322 /s/ Patrick Kirwin, by Max Milbury, Attorney-in-Fact 2022-12-15