<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:ns0="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001951275</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001921865</issuerCik>
<issuerName>ASP Isotopes Inc.</issuerName>
<secFileNumber>001-41555</secFileNumber>
<issuerAddress>
<ns0:street1>2200 Ross Avenue</ns0:street1>
<ns0:street2>Suite 4575E</ns0:street2>
<ns0:city>Dallas</ns0:city>
<ns0:stateOrCountry>TX</ns0:stateOrCountry>
<ns0:zipCode>75201</ns0:zipCode>
</issuerAddress>
<issuerContactPhone>(214) 4328219</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Ainscow Robert</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>OFFICER</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>Independent Trading Group (ITG) Inc.</name>
<address>
<ns0:street1>33 Yonge Street </ns0:street1>
<ns0:street2>Suite 420</ns0:street2>
<ns0:city>Toronto</ns0:city>
<ns0:stateOrCountry>A6</ns0:stateOrCountry>
<ns0:zipCode>M5E 1G4</ns0:zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>25000</noOfUnitsSold>
<aggregateMarketValue>112000</aggregateMarketValue>
<noOfUnitsOutstanding>125903447</noOfUnitsOutstanding>
<approxSaleDate>04/13/2026</approxSaleDate>
<securitiesExchangeName>NASDAQ</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>09/06/2024</acquiredDate>
<natureOfAcquisitionTransaction>Acquired as compensation --Restricted Stock Award</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>300000</amountOfSecuritiesAcquired>
<paymentDate>09/06/2024</paymentDate>
<natureOfPayment>Equity Compensation</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<securitiesSoldInPast3Months>
<sellerDetails>
<name>Ainscow Robert</name>
<address>
<ns0:street1>c/o ASP Isotopes Inc.</ns0:street1>
<ns0:street2>2200 Ross Avenue, Suite 4575E</ns0:street2>
<ns0:city>Dallas</ns0:city>
<ns0:stateOrCountry>TX</ns0:stateOrCountry>
<ns0:zipCode>75201</ns0:zipCode>
</address>
</sellerDetails>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<saleDate>03/06/2026</saleDate>
<amountOfSecuritiesSold>8438</amountOfSecuritiesSold>
<grossProceeds>45894.28</grossProceeds>
</securitiesSoldInPast3Months>
<remarks>The sale of shares reported in this Form 144 is expected to be sold on the date indicated pursuant to a Rule 10b5-1 trading plan. The Aggregate Market Value of the shares to be sold is based on the closing market price of $4.48 on April 10, 2026.</remarks>
<noticeSignature>
<noticeDate>04/13/2026</noticeDate>
<planAdoptionDates>
<planAdoptionDate>12/13/2024</planAdoptionDate>
</planAdoptionDates>
<signature>/s/ Robert Ainscow</signature>
</noticeSignature>
</formData>
</edgarSubmission>
