<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
<headerData>
<submissionType>SCHEDULE 13G/A</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001921222</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>



</filerInfo>
</headerData>
<formData>
<coverPageHeader>
<amendmentNo>3</amendmentNo>
<securitiesClassTitle>Common Stock, par value $0.001 per share</securitiesClassTitle>
<eventDateRequiresFilingThisStatement>09/30/2025</eventDateRequiresFilingThisStatement>
<issuerInfo>
<issuerCik>0000949858</issuerCik>
<issuerName>ACHIEVE LIFE SCIENCES, INC.</issuerName>
<issuerCusip>004468500</issuerCusip>
<issuerPrincipalExecutiveOfficeAddress>
<com:street1>22722 29TH DR. SE</com:street1>
<com:street2>SUITE 100</com:street2>
<com:city>SEATTLE</com:city>
<com:stateOrCountry>WA</com:stateOrCountry>
<com:zipCode>98021</com:zipCode>
</issuerPrincipalExecutiveOfficeAddress>
</issuerInfo>
<designateRulesPursuantThisScheduleFiled>
<designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
</designateRulesPursuantThisScheduleFiled>
</coverPageHeader>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Contrarian Alpha, LP</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>550000</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>550000</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>550000</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>1.1</classPercent>
<typeOfReportingPerson>PN</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Contrarian Achieve SPV, LP</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>1978377</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>1978377</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1978377</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>3.8</classPercent>
<typeOfReportingPerson>PN</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Contrarian Achieve GP LLC</reportingPersonName>
<citizenshipOrOrganization>DE</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>1978377</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>1978377</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1978377</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>3.8</classPercent>
<typeOfReportingPerson>IA</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Contrarian Alpha GP, LLC</reportingPersonName>
<citizenshipOrOrganization>NY</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>550000</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>550000</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>550000</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>1.1</classPercent>
<typeOfReportingPerson>IA</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Contrarian Alpha Management, LLC</reportingPersonName>
<citizenshipOrOrganization>NY</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>550000</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>550000</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>550000</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>1.1</classPercent>
<typeOfReportingPerson>IA</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<coverPageHeaderReportingPersonDetails>

<reportingPersonName>Parker Quillen</reportingPersonName>
<citizenshipOrOrganization>X1</citizenshipOrOrganization>
<reportingPersonBeneficiallyOwnedNumberOfShares>
<soleVotingPower>0</soleVotingPower>
<sharedVotingPower>2528377</sharedVotingPower>
<soleDispositivePower>0</soleDispositivePower>
<sharedDispositivePower>2528377</sharedDispositivePower>
</reportingPersonBeneficiallyOwnedNumberOfShares>
<reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2528377</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
<aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
<classPercent>4.9</classPercent>
<typeOfReportingPerson>IN</typeOfReportingPerson>
</coverPageHeaderReportingPersonDetails>
<items>
<item1>
<issuerName>ACHIEVE LIFE SCIENCES, INC.</issuerName>
<issuerPrincipalExecutiveOfficeAddress>22722 29TH DR. SE, SUITE 100, SEATTLE, Washington, 98021</issuerPrincipalExecutiveOfficeAddress>
</item1>
<item2>
<filingPersonName>The names of the persons filing this statement on Schedule 13G are (collectively, the "Reporting Persons"):&#13;
&#13;
Contrarian Achieve SPV LP, a Delaware limited partnership ("Contrarian Achieve");&#13;
&#13;
Contrarian Alpha, LP, a Delaware limited partnership ("Contrarian Alpha");&#13;
&#13;
Contrarian Achieve GP LLC, a Delaware limited liability company ("Achieve GP");&#13;
&#13;
Contrarian Alpha GP, LLC, a New York limited liability company ("Alpha GP");&#13;
&#13;
Contrarian Alpha Management, LLC, a New York limited liability company ("Contrarian Alpha Management"); and&#13;
&#13;
Parker Quillen, a United States citizen ("Mr. Quillen");</filingPersonName>
<principalBusinessOfficeOrResidenceAddress>The principal business address of each of the Reporting Persons is 22 Fieldview Lane, East Hampton, NY 11937.</principalBusinessOfficeOrResidenceAddress>
<citizenship>Contrarian Achieve is a Delaware limited partnership&#13;
Contrarian Alpha is a Delaware limited partnership&#13;
Achieve GP is a Delaware limited liability company&#13;
Alpha GP is a New York limited liability company&#13;
Contrarian Alpha Management is a New York limited liability company&#13;
Mr. Quillen is a citizen of the United States.</citizenship>
</item2>
<item3>
<notApplicableFlag>Y</notApplicableFlag>
</item3>
<item4>
<amountBeneficiallyOwned>As of November 14, 2025:&#13;
&#13;
Contrarian Achieve beneficially owned a total of 1,978,377 shares of Common Stock consisting of 1,318,918 shares of Common Stock held directly and warrants currently exercisable for 659,459 shares of Common Stock.&#13;
&#13;
Contrarian Alpha beneficially owned a total of 550,000 shares of Common Stock consisting of 350,000 shares of Common Stock held directly and warrants currently exercisable for 200,000 shares of Common Stock.&#13;
&#13;
Achieve GP, as the general partner of Contrarian Achieve, may be deemed to beneficially own the total of 1,978,377 shares of Common Stock beneficially owned by Contrarian Achieve.&#13;
&#13;
Alpha GP, as the general partner of Contrarian Alpha, may be deemed to beneficially own the total of 550,000 shares of Common Stock beneficially owned by Contrarian Alpha.&#13;
&#13;
Contrarian Alpha Management, as the investment manager of Contrarian Alpha, may be deemed to beneficially own the total of 550,000 shares of Common Stock beneficially owned by Contrarian Alpha.&#13;
&#13;
Mr. Quillen, as the manager of Achieve GP and Alpha GP, may be deemed to beneficially own the total of 2,528,377 shares of Common Stock beneficially owned by Achieve GP and Alpha GP.</amountBeneficiallyOwned>
<classPercent>The following percentage is based on 51,104,968 shares of Common Stock outstanding as of August 7, 2025, as disclosed in the Issuer's Current Report on Form 10-Q filed with the Securities and Exchange Commission on August 7, 2025.&#13;
&#13;
As of November 14, 2025, the Reporting Persons may be deemed to have beneficially owned approximately 4.9% of the outstanding Common Stock.</classPercent>
<numberOfSharesPersonHas>
<solePowerOrDirectToVote>See Cover Pages Items 5-8.</solePowerOrDirectToVote>
<sharedPowerOrDirectToVote>See Cover Pages Items 5-8.</sharedPowerOrDirectToVote>
<solePowerOrDirectToDispose>See Cover Pages Items 5-8.</solePowerOrDirectToDispose>
<sharedPowerOrDirectToDispose>See Cover Pages Items 5-8.</sharedPowerOrDirectToDispose>
</numberOfSharesPersonHas>
</item4>
<item5>
<notApplicableFlag>N</notApplicableFlag>
<classOwnership5PercentOrLess>Y</classOwnership5PercentOrLess>
</item5>
<item6>
<notApplicableFlag>Y</notApplicableFlag>
</item6>
<item7>
<notApplicableFlag>Y</notApplicableFlag>
</item7>
<item8>
<notApplicableFlag>N</notApplicableFlag>
<identificationAndClassificationOfGroupMembers>See Exhibit A to the Schedule 13G filed by the Reporting Persons with respect to the Issuer on November 28, 2022.</identificationAndClassificationOfGroupMembers>
</item8>
<item9>
<notApplicableFlag>Y</notApplicableFlag>
</item9>
<item10>
<notApplicableFlag>N</notApplicableFlag>
<certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
</item10>
</items>
<signatureInformation>
<reportingPersonName>Contrarian Alpha, LP</reportingPersonName>
<signatureDetails>
<signature>/s/ Parker Quillen</signature>
<title>Parker Quillen, Manager, Contrarian Achieve GP LLC, general partner</title>
<date>11/14/2025</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>Contrarian Achieve SPV, LP</reportingPersonName>
<signatureDetails>
<signature>/s/ Parker Quillen</signature>
<title>Parker Quillen, Manager, Contrarian Achieve GP LLC, general partner</title>
<date>11/14/2025</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>Contrarian Achieve GP LLC</reportingPersonName>
<signatureDetails>
<signature>/s/ Parker Quillen</signature>
<title>Parker Quillen, Manager</title>
<date>11/14/2025</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>Contrarian Alpha GP, LLC</reportingPersonName>
<signatureDetails>
<signature>/s/ Parker Quillen</signature>
<title>Parker Quillen, Manager</title>
<date>11/14/2025</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>Contrarian Alpha Management, LLC</reportingPersonName>
<signatureDetails>
<signature>/s/ Parker Quillen</signature>
<title>Parker Quillen, Manager</title>
<date>11/14/2025</date>
</signatureDetails>
</signatureInformation>
<signatureInformation>
<reportingPersonName>Parker Quillen</reportingPersonName>
<signatureDetails>
<signature>/s/ Parker Quillen</signature>
<title>Parker Quillen</title>
<date>11/07/2025</date>
</signatureDetails>
</signatureInformation>
</formData>
</edgarSubmission>
