X0306 4 2022-08-10 0 0001404644 Neoleukin Therapeutics, Inc. NLTX 0001914769 Smith Sean Michael C/O NEOLEUKIN THERAPEUTICS, INC. 188 EAST BLAINE STREET, #450 SEATTLE WA 98102 0 1 0 0 Principal Accounting Officer Common Stock 2022-08-10 4 M 0 5000 0.00 A 8431 D Common Stock 2022-08-10 4 S 0 1655 0.9914 D 6776 D Restricted Stock Units 0.00 2022-08-10 4 M 0 5000 0.00 D Common Stock 5000 5000 D The sales reported on this Form 4 represent shares required to be sold by the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units ("RSUs"). These sales are mandated by the Issuer's election under its equity incentive plans to require the satisfaction of tax withholding obligations to be funded by a "sell to cover" transaction and do not represent discretionary trades by the Reporting Person. Represents the weighted average sale price. The lowest price at which shares were sold was $.9801 and the highest price at which shares were sold was $1.01. The Reporting Person undertakes to provide upon request to the staff of the Securities and Exchange Commission, the Issuer or its stockholders, full information regarding the total number of shares sold at each separate price within the range set forth herein. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock upon settlement for no consideration. The RSUs will vest as to 1/2 of the total number of shares underlying the award on each of August 10, 2022 and August 10, 2023, subject to the Reporting Person's provision of service to the Issuer on each vesting date. The RSUs do not expire; these securities either vest and settle or are canceled prior to the vesting date. /s/ Sean Smith 2022-08-12