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    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001912966</cik>
        <entityName>REGENTIS BIOMATERIALS LTD.</entityName>
        <issuerAddress>
            <street1>60 MEDINAT HAYEHUDIM STREET</street1>
            <city>HERZLIYA</city>
            <stateOrCountry>L3</stateOrCountry>
            <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
            <zipCode>4676652</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>+972 (9) 960-1917</issuerPhoneNumber>
        <jurisdictionOfInc>ISRAEL</jurisdictionOfInc>
        <issuerPreviousNameList>
            <value>None</value>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <value>None</value>
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        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ehud</firstName>
                <lastName>Geller</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Regentis Biomaterials Ltd.</street1>
                <street2>60 Medinat Hayehudim Street</street2>
                <city>Herzliya</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4676652</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ori</firstName>
                <lastName>Gon</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Regentis Biomaterials Ltd.</street1>
                <street2>60 Medinat Hayehudim Street60 Medinat Ha</street2>
                <city>Herzliya</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4676652</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
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        </relatedPersonInfo>
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            <relatedPersonName>
                <firstName>Arie</firstName>
                <lastName>Gordashnikov</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Regentis Biomaterials Ltd.</street1>
                <street2>60 Medinat Hayehudim Street</street2>
                <city>Herzliya</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4676652</zipCode>
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            <relatedPersonRelationshipList>
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                <firstName>Galit</firstName>
                <lastName>Reske</lastName>
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                <street1>Regentis Biomaterials Ltd.</street1>
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                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
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                <firstName>Jeff</firstName>
                <lastName>Dykan</lastName>
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                <street1>Regentis Biomaterials Ltd.</street1>
                <street2>60 Medinat Hayehudim Street</street2>
                <city>Herzliya</city>
                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
                <zipCode>4676652</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Keith</firstName>
                <lastName>Valentine</lastName>
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                <street1>Regentis Biomaterials Ltd.</street1>
                <street2>60 Medinat Hayehudim Street</street2>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Efraim</firstName>
                <lastName>Cohen-Arazi</lastName>
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            <relatedPersonAddress>
                <street1>Regentis Biomaterials Ltd.</street1>
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                <relationship>Director</relationship>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Pini</firstName>
                <lastName>Ben-Elazar</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Regentis Biomaterials Ltd.</street1>
                <street2>60 Medinat Hayehudim Street</street2>
                <city>Herzliya</city>
                <stateOrCountry>L3</stateOrCountry>
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            <relatedPersonRelationshipList>
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        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Susan</firstName>
                <lastName>Alpert</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>Regentis Biomaterials Ltd.</street1>
                <street2>60 Medinat Hayehudim Street</street2>
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                <stateOrCountry>L3</stateOrCountry>
                <stateOrCountryDescription>ISRAEL</stateOrCountryDescription>
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            <relatedPersonRelationshipList>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06c</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2026-06-17</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
            <isOptionToAcquireType>true</isOptionToAcquireType>
            <isSecurityToBeAcquiredType>true</isSecurityToBeAcquiredType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>0</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>ThinkEquity LLC</recipientName>
                <recipientCRDNumber>000020996</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>17 State Street</street1>
                    <street2>41st  Floor</street2>
                    <city>NY</city>
                    <stateOrCountry>NY</stateOrCountry>
                    <stateOrCountryDescription>NEW YORK</stateOrCountryDescription>
                    <zipCode>10004</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AZ</state>
                    <description>ARIZONA</description>
                    <state>CA</state>
                    <description>CALIFORNIA</description>
                    <state>CT</state>
                    <description>CONNECTICUT</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>ID</state>
                    <description>IDAHO</description>
                    <state>IL</state>
                    <description>ILLINOIS</description>
                    <state>MA</state>
                    <description>MASSACHUSETTS</description>
                    <state>NJ</state>
                    <description>NEW JERSEY</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                    <state>WA</state>
                    <description>WASHINGTON</description>
                    <state>WI</state>
                    <description>WISCONSIN</description>
                </statesOfSolicitationList>
                <foreignSolicitation>true</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>6500000</totalOfferingAmount>
            <totalAmountSold>6500000</totalAmountSold>
            <totalRemaining>0</totalRemaining>
            <clarificationOfResponse>An offering of 1,844,543 ordinary shares, 12,600 pre-funded warrants and 1,857,143 ordinary warrants, at a purchase price of $3.50 per share and ordinary warrant and $3.4999 per pre-funded warrant and ordinary warrant.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>22</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>455000</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>The Placement Agent also received a $180,000 accountable expense reimbursement, a non-accountable expense allowance of $65,000 and 92,857 unregistered warrants to purchase ordinary shares.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>The Company intends to use the proceeds from the Offering to support its clinical trials and submissions to the FDA, advance its technology, support its operations and intellectual property and for working capital and general corporate purposes.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>REGENTIS BIOMATERIALS LTD.</issuerName>
                <signatureName>/s/ Ori Gon</signatureName>
                <nameOfSigner>Ori Gon</nameOfSigner>
                <signatureTitle>Chief Financial Officer</signatureTitle>
                <signatureDate>2026-06-25</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
