<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001912570</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001583648</issuerCik>
      <issuerName>PALVELLA THERAPEUTICS, INC.</issuerName>
      <secFileNumber>001-37471</secFileNumber>
      <issuerAddress>
        <com:street1>353 W. LANCASTER AVENUE</com:street1>
        <com:street2>SUITE 200</com:street2>
        <com:city>WAYNE</com:city>
        <com:stateOrCountry>PA</com:stateOrCountry>
        <com:zipCode>19087</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>(484) 253-1461</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Goin Kathleen</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Piper Sandler &amp; Co Inc</name>
        <address>
          <com:street1>350 N 5th St</com:street1>
          <com:street2>Ste 1000</com:street2>
          <com:city>Minneapolis</com:city>
          <com:stateOrCountry>MN</com:stateOrCountry>
          <com:zipCode>55401</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>4302</noOfUnitsSold>
      <aggregateMarketValue>476372.94</aggregateMarketValue>
      <noOfUnitsOutstanding>14342844</noOfUnitsOutstanding>
      <approxSaleDate>06/17/2026</approxSaleDate>
      <securitiesExchangeName>Nasdaq</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>06/17/2026</acquiredDate>
      <natureOfAcquisitionTransaction>Stock Option Exercise</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>4302</amountOfSecuritiesAcquired>
      <paymentDate>06/17/2026</paymentDate>
      <natureOfPayment>Cash</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kathleen Goin C/O Palvella Therapeutics Inc</name>
        <address>
          <com:street1>353 W Lancaster Ave</com:street1>
          <com:street2>Ste 200</com:street2>
          <com:city>Wayne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>03/18/2026</saleDate>
      <amountOfSecuritiesSold>4302</amountOfSecuritiesSold>
      <grossProceeds>507611.05</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kathleen Goin C/O Palvella Therapeutics Inc</name>
        <address>
          <com:street1>353 W Lancaster Ave</com:street1>
          <com:street2>Ste 200</com:street2>
          <com:city>Wayne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>04/15/2026</saleDate>
      <amountOfSecuritiesSold>4302</amountOfSecuritiesSold>
      <grossProceeds>547398.96</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Kathleen Goin C/O Palvella Therapeutics Inc</name>
        <address>
          <com:street1>353 W Lancaster Ave, Ste 200</com:street1>
          <com:city>Wayne</com:city>
          <com:stateOrCountry>PA</com:stateOrCountry>
          <com:zipCode>19087</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>05/20/2026</saleDate>
      <amountOfSecuritiesSold>4302</amountOfSecuritiesSold>
      <grossProceeds>475630.84</grossProceeds>
    </securitiesSoldInPast3Months>
    <noticeSignature>
      <noticeDate>06/17/2026</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>08/19/2025</planAdoptionDate>
      </planAdoptionDates>
      <signature>Alex Johnson, a duly authorized representative of Piper Sandler &amp; Co Corporate &amp; Venture Services FA, as attorney-in-fact for Kathleen Goin</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
